Treffer: Effects of an energy and micronutrient supplement on skeletal maturation in undernourished children in Indonesia.

Title:
Effects of an energy and micronutrient supplement on skeletal maturation in undernourished children in Indonesia.
Authors:
Jahari AB; Nutrition Research and Development Center, Bogor, Indonesia., Haas J, Husaini MA, Pollitt E
Source:
European journal of clinical nutrition [Eur J Clin Nutr] 2000 May; Vol. 54 Suppl 2, pp. S74-9.
Publication Type:
Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Language:
English
Journal Info:
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8804070 Publication Model: Print Cited Medium: Print ISSN: 0954-3007 (Print) Linking ISSN: 09543007 NLM ISO Abbreviation: Eur J Clin Nutr Subsets: MEDLINE
Imprint Name(s):
Publication: <2003->: London : Nature Publishing Group
Original Publication: London : J. Libbey, c1988-
MeSH Terms:
Bone Development* , Dietary Supplements* , Infant Nutritional Physiological Phenomena*, Child Development/*physiology , Energy Intake/*physiology , Micronutrients/*administration & dosage, Age Determination by Skeleton ; Age Factors ; Bone and Bones/diagnostic imaging ; Cohort Studies ; Female ; Humans ; Indonesia ; Infant ; Male
Substance Nomenclature:
0 (Micronutrients)
Entry Date(s):
Date Created: 20000721 Date Completed: 20001228 Latest Revision: 20191104
Update Code:
20250114
DOI:
10.1038/sj.ejcn.1601008
PMID:
10902990
Database:
MEDLINE

Weitere Informationen

Objectives: This paper reports the effects of an energy and micronutrient supplement on skeletal maturation of nutritionally at risk infants and toddlers in Pangalengan, Indonesia.
Design: Two cohorts of children were randomly assigned to three treatments: E = 1171 kJoule + 12 mg iron; M = 12 mg iron + 209 kJ; S = 104 kJ. Supplementation was given for 12 months.
Setting: The sites were six tea plantations in Pangalengan, West Java.
Subjects: A 12-month-old (n = 53) and an 18-month-old (n = 83) cohort were recruited from day-care-centers. Twenty children that received S belonged to the 12- and 18-month-old cohorts. Inclusion criteria were: no chronic disease; length-for-age < or = -1 standard deviation (s.d.) and weight-for-length between -1 and -2 s.d. of the median of the reference of the World Health Organization.
Methods: Skeletal maturation was measured by X-ray of the left hand and wrist. The number of ossified centers and two different measures of skeletal age (Skel-1 and Skel-2) were the outcome variables measured.
Results: In the 12-month-old cohort, there were intergroup differences 6 and 12 months after baseline. First, the children in the E group were about 2 months more advanced in ossified centers than the children in the S group (P < 0.10). At 12 months, the children in the E group were about 3 months more advanced in skeletal age than the children in the M group. M group children were about 2.5 months behind the children in the S group.