• Life course study of the etiol...

Treffer: Life course study of the etiology of self-reported irritable bowel syndrome in the 1958 British birth cohort.

Title:
Life course study of the etiology of self-reported irritable bowel syndrome in the 1958 British birth cohort.
Authors:
Goodwin L; Centre for Psychiatry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK. l.goodwin@qmul.ac.uk, White PD, Hotopf M, Stansfeld SA, Clark C
Source:
Psychosomatic medicine [Psychosom Med] 2013 Feb; Vol. 75 (2), pp. 202-10. Date of Electronic Publication: 2013 Jan 16.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
Language:
English
Journal Info:
Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0376505 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-7796 (Electronic) Linking ISSN: 00333174 NLM ISO Abbreviation: Psychosom Med Subsets: MEDLINE
Imprint Name(s):
Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Baltimore [etc.]
MeSH Terms:
Life Change Events*, Chronic Disease/*epidemiology , Irritable Bowel Syndrome/*epidemiology , Stress, Psychological/*epidemiology, Abdominal Pain/epidemiology ; Adolescent ; Adult ; Age of Onset ; Anxiety/epidemiology ; Body Mass Index ; Child ; Child Abuse/statistics & numerical data ; Depression/epidemiology ; Epidemiologic Methods ; Female ; Humans ; Irritable Bowel Syndrome/etiology ; Irritable Bowel Syndrome/psychology ; Male ; Motor Activity ; Sex Factors ; Socioeconomic Factors ; United Kingdom/epidemiology ; Young Adult
Grant Information:
G1001799 United Kingdom MRC_ Medical Research Council; G0701032 United Kingdom MRC_ Medical Research Council
Entry Date(s):
Date Created: 20130118 Date Completed: 20130806 Latest Revision: 20250529
Update Code:
20250530
DOI:
10.1097/PSY.0b013e31827c351b
PMID:
23324872
Database:
MEDLINE

Weitere Informationen

Objective: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder with unknown etiology. This is the first study to use a life course approach to examine premorbid risk markers for self-reported IBS in a UK birth cohort.
Methods: Cohort study using the 1958 British birth cohort, which included 98.7% of births in 1 week in England, Wales, and Scotland. The outcome was self-reported IBS by the age of 42 years, classified with onset after 24 years and onset after 34 years. Childhood psychopathology was assessed by the Rutter scales, and adulthood psychopathology was assessed by the Malaise Inventory.
Results: The prevalence of self-reported IBS in this cohort was 8.4% by 42 years (95% confidence interval [CI]=8.2-8.6). In multivariate analyses, being female (odds ratio [OR]=2.00, 95% CI=1.67-2.36), reporting 1 week to 1 month of school absence for ill health at 16 years (OR=1.27, 95% CI=1.03-1.56) and psychopathology at 23 years (OR=1.25, 95% CI=1.01-1.54) and 33 years (OR=2.20, 95% CI=1.74-2.76) were associated with an increased odds for IBS. Prospectively measured childhood adversity showed no significant association.
Conclusions: This is the first study to show a long-term prospective link between premorbid psychopathology and later self-reported IBS, in agreement with previous findings on chronic fatigue syndrome. There is no evidence that prospective measures of childhood adversity are risk markers for IBS, and there is weak evidence that prospective measures of childhood illness at 16 years are risk markers for IBS, differing to results from the same cohort for psychopathology, chronic fatigue syndrome, and chronic widespread pain. This study also does not replicate the findings of retrospective studies examining the etiology of IBS.