Treffer: Breast cancer clinical characteristics and outcomes in Trinidad and Tobago.

Title:
Breast cancer clinical characteristics and outcomes in Trinidad and Tobago.
Authors:
Camacho-Rivera M; Hofstra North Shore-LIJ School of Medicine, North Shore/LIJ Health System, 175 Community Drive, Rm 203, Great Neck, NY, 11021, USA., Ragin C, Roach V, Kalwar T, Taioli E
Source:
Journal of immigrant and minority health [J Immigr Minor Health] 2015 Jun; Vol. 17 (3), pp. 765-72.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Springer Country of Publication: United States NLM ID: 101256527 Publication Model: Print Cited Medium: Internet ISSN: 1557-1920 (Electronic) Linking ISSN: 15571912 NLM ISO Abbreviation: J Immigr Minor Health Subsets: MEDLINE
Imprint Name(s):
Original Publication: New York, NY : Springer, c 2006-
MeSH Terms:
Breast Neoplasms/*diagnosis , Breast Neoplasms/*therapy, Adult ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Carcinoma/diagnosis ; Carcinoma/metabolism ; Carcinoma/pathology ; Carcinoma/therapy ; Combined Modality Therapy/statistics & numerical data ; Delayed Diagnosis ; Female ; Humans ; Middle Aged ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Registries ; Trinidad and Tobago
Comments:
Erratum in: J Immigr Minor Health. 2015 Jun;17(3):980. doi: 10.1007/s10903-014-0020-0. (PMID: 24752981)
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Substance Nomenclature:
0 (Receptors, Estrogen)
0 (Receptors, Progesterone)
Entry Date(s):
Date Created: 20131023 Date Completed: 20161213 Latest Revision: 20220408
Update Code:
20250114
DOI:
10.1007/s10903-013-9930-5
PMID:
24146313
Database:
MEDLINE

Weitere Informationen

Trinidad and Tobago (TT) is the country with the highest breast cancer mortality in the Caribbean. It is unknown whether biological, behavioral, environmental, or clinical factors play a significant role in such outcome. A total of 2,614 incident cases, histologically confirmed and recorded in the TT cancer registries between 1995 and 2005, with follow-up through 2009 were analyzed. Half of the cases were diagnosed between the ages of 40-59 years, 12.5% before the age of 40 years; 45% of women were diagnosed at localized stage and 43.7% were hormone receptor positive. Women diagnosed with distant staging were more likely to undergo chemotherapy compared to those with localized staging (OR 1.39; 95% CI 1.01-1.89). Hormone receptor negative cases were significantly less likely to undergo radiation or surgery therapy (OR 0.66; 95% CI 0.56-0.79 and OR 0.67; 95% CI 0.51-0.88 respectively) compared to those who were hormone receptor positive, but more than 1.5 times as likely to undergo chemotherapy. In multivariate analyses, advanced stage disease and negative hormone receptor status were independently significantly associated with poorer survival outcome. No racial/ethnic differences were observed with respect to treatment or survival. Although access to breast cancer screening and treatment is free in Trinidad and Tobago, breast cancer diagnosis occurs at advanced stages; use of multimodality therapy as a first course of treatment is low.