Treffer: Modeling loop structures in proteins and nucleic acids: an RNA stem-loop.
Title:
Modeling loop structures in proteins and nucleic acids: an RNA stem-loop.
Authors:
Source:
Journal of molecular graphics [J Mol Graph] 1989 Dec; Vol. 7 (4), pp. 186-95.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
Language:
English
Journal Info:
Publisher: Butterworth-Heinemann In Association With The Molecular Graphics Society Country of Publication: United States NLM ID: 9014762 Publication Model: Print Cited Medium: Print ISSN: 0263-7855 (Print) Linking ISSN: 02637855 NLM ISO Abbreviation: J Mol Graph Subsets: MEDLINE
Imprint Name(s):
Publication: Stoneham Ma : Butterworth-Heinemann In Association With The Molecular Graphics Society
Original Publication: Guildford : Butterworth Scientific Ltd., c1983-c1996.
Original Publication: Guildford : Butterworth Scientific Ltd., c1983-c1996.
MeSH Terms:
Substance Nomenclature:
0 (RNA, Transfer, Asp)
63231-63-0 (RNA)
63231-63-0 (RNA)
Entry Date(s):
Date Created: 19891201 Date Completed: 19910226 Latest Revision: 20191029
Update Code:
20250114
DOI:
10.1016/0263-7855(89)80001-3
PMID:
2484809
Database:
MEDLINE
Weitere Informationen
We have used a novel modeling technique, based on combining information from several preexisting structures, to generate a three-dimensional (3D) model for the RNA stem-loop responsible for translational repression of the MS2 RNA bacteriophage replicase. Specific features of the model have been tested experimentally by chemical and enzymatic structural probes; results from these experiments have been used to "improve" the model by fixing initial assumptions. The new model and chemical modification data are in part consistent, and further predictions are being tested. The modeling algorithm has a wide range of potential applications, particularly to loop regions in proteins and nucleic acids.