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Treffer: Trends of Systemic Therapy Use for Renal Cell Carcinoma in the United States.

Title:
Trends of Systemic Therapy Use for Renal Cell Carcinoma in the United States.
Authors:
Ferry EK; Urology Institute, University Hospitals Case Medical Center, Cleveland, OH. Electronic address: Elizabeth.Ferry@UHhospitals.org., Minnillo BJ; Urology Institute, University Hospitals Case Medical Center, Cleveland, OH., Maurice MJ; Urology Institute, University Hospitals Case Medical Center, Cleveland, OH., Abouassaly R; Urology Institute, University Hospitals Case Medical Center, Cleveland, OH; Case Western Reserve University School of Medicine, Cleveland, OH., Zhu H; Case Western Reserve University School of Medicine, Cleveland, OH; Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH; Department of Urology, Glickman Urological and Kidney Institute, Cleveland, OH; Cleveland Clinic, Cleveland, OH.
Source:
Urology [Urology] 2015 Jun; Vol. 85 (6), pp. 1399-403.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Elsevier Science Country of Publication: United States NLM ID: 0366151 Publication Model: Print Cited Medium: Internet ISSN: 1527-9995 (Electronic) Linking ISSN: 00904295 NLM ISO Abbreviation: Urology Subsets: MEDLINE
Imprint Name(s):
Publication: New York : Elsevier Science
Original Publication: Ridgewood, N.J., Professional Medical Services Co.
MeSH Terms:
Carcinoma, Renal Cell/*therapy , Immunotherapy/*statistics & numerical data , Immunotherapy/*trends , Kidney Neoplasms/*therapy, Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; United States
Entry Date(s):
Date Created: 20150624 Date Completed: 20150908 Latest Revision: 20220317
Update Code:
20250114
DOI:
10.1016/j.urology.2015.03.008
PMID:
26099886
Database:
MEDLINE

Weitere Informationen

Objective: To assess the utilization of immunotherapy after the advent of tyrosine-kinase inhibitors and mammalian target of rapamycin inhibitors for metastatic renal cell carcinoma (RCC) in the United States, as well as to better understand the variables associated with the implementation of these systemic therapies.
Methods: The National Cancer Data Base Participant User File for Renal Cancer was queried. Patients diagnosed with metastatic RCC were identified. From that group, patients who received either immunotherapy or chemotherapy (single or multiagent), given as a first-course therapy from 1998 to 2011 were selected. Multivariate analysis was used to assess patient, disease, and provider factors associated with immunotherapy or chemotherapy overall usage between 2003 and 2011.
Results: A total of 25,186 patients diagnosed with metastatic RCC were identified; 3107 received immunotherapy and 8640 received chemotherapy. The use of immunotherapy decreased from 30.3% in 1998 to 3.8% in 2011. The use of chemotherapy increased from 16.2% in 1998 to 54.0% in 2011. The most dramatic period of change was from 2004 to 2006. Independent negative predictors of receiving immunotherapy included progressive years of diagnosis (P <.0001), increasing age (P <.0001), female gender (P = .001), and African American race (P = .04).
Conclusion: There has been a significant decrease in the use of immunotherapy for metastatic RCC in the United States since the introduction of targeted chemotherapeutic agents in the past decade.
(Copyright © 2015 Elsevier Inc. All rights reserved.)