Treffer: Surgical Ventricular Entry is a Key Risk Factor for Leptomeningeal Metastasis of High Grade Gliomas.
Title:
Surgical Ventricular Entry is a Key Risk Factor for Leptomeningeal Metastasis of High Grade Gliomas.
Authors:
Roelz R; Department of Neurosurgery, University Medical Center Freiburg, Breisacher Str. 64, 79106 Freiburg, Germany.; Department of Stereotactic and Functional Neurosurgery, University Medical Center Freiburg, Breisacher Str. 64, 79106 Freiburg., Reinacher P; Department of Stereotactic and Functional Neurosurgery, University Medical Center Freiburg, Breisacher Str. 64, 79106 Freiburg., Jabbarli R; Department of Neurosurgery, University Medical Center Freiburg, Breisacher Str. 64, 79106 Freiburg, Germany.; Department of Neurosurgery, University Hospital Essen, Hufelandstr. 55, 45147, Germany., Kraeutle R; Department of Nursing-IT, University Medical Center Freiburg, Hugstetter Str. 55, 79106 Freiburg., Hippchen B; Department of Neurosurgery, University Medical Center Freiburg, Breisacher Str. 64, 79106 Freiburg, Germany., Egger K; Department of Neuroradiology, University Medical Center Freiburg, Breisacher Str. 64, 79106 Freiburg, Germany., Weyerbrock A; Department of Neurosurgery, University Medical Center Freiburg, Breisacher Str. 64, 79106 Freiburg, Germany., Machein M; Department of Neurosurgery, University Medical Center Freiburg, Breisacher Str. 64, 79106 Freiburg, Germany.
Source:
Scientific reports [Sci Rep] 2015 Dec 04; Vol. 5, pp. 17758. Date of Electronic Publication: 2015 Dec 04.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Imprint Name(s):
Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:
Cerebral Ventricles/*surgery , Glioma/*surgery , Meningeal Neoplasms/*pathology , Vascular Surgical Procedures/*adverse effects, Adult ; Aged ; Aged, 80 and over ; Cerebral Ventriculography ; Female ; Glioma/complications ; Glioma/diagnostic imaging ; Glioma/pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Meningeal Neoplasms/diagnostic imaging ; Meningeal Neoplasms/etiology ; Meningeal Neoplasms/secondary ; Middle Aged ; Neoplasm Metastasis ; Prognosis ; Risk Factors
References:
Int J Radiat Oncol Biol Phys. 1981 Dec;7(12):1661-5. (PMID: 6977517)
Int J Radiat Oncol Biol Phys. 2013 Jul 15;86(4):616-22. (PMID: 23540348)
Int J Radiat Oncol Biol Phys. 2013 Jul 15;86(4):609-15. (PMID: 23462418)
Neuro Oncol. 2014 May;16(5):719-27. (PMID: 24463354)
Neurosurgery. 1986 Aug;19(2):247-51. (PMID: 3748352)
Int J Radiat Oncol Biol Phys. 2013 Jul 15;86(4):606-8. (PMID: 23773389)
J Neurooncol. 2004 Jan;66(1-2):209-16. (PMID: 15015789)
Neuroradiol J. 2013 Oct;26(5):542-7. (PMID: 24199814)
Cancer. 1978 Dec;42(6):2854-64. (PMID: 215298)
J Neurosurg. 2003 Nov;99(5):854-62. (PMID: 14609165)
Neurosurgery. 1989 Oct;25(4):533-40. (PMID: 2797391)
Am J Clin Pathol. 2007 Apr;127(4):585-90. (PMID: 17369134)
Neuro Oncol. 2002 Apr;4(2):129-33. (PMID: 11916505)
Lancet Oncol. 2006 May;7(5):392-401. (PMID: 16648043)
J Neurooncol. 2003 Jun;63(2):191-9. (PMID: 12825824)
Radiology. 1991 Feb;178(2):467-74. (PMID: 1987610)
J Clin Neurosci. 2004 Jan;11(1):37-41. (PMID: 14642363)
Neurosurgery. 1992 Jan;30(1):64-71. (PMID: 1738457)
J Biol Chem. 1999 Jul 16;274(29):20693-703. (PMID: 10400703)
Tumour Biol. 2014 Jul;35(7):6687-93. (PMID: 24705863)
Neuro Oncol. 2008 Feb;10(1):79-87. (PMID: 17993634)
J Neurooncol. 2014 Feb;116(3):617-23. (PMID: 24401959)
Surg Neurol. 2001 Jul;56(1):33-7; discussion 37-8. (PMID: 11546569)
J Neurooncol. 1998 May;37(3):285-93. (PMID: 9524086)
Cancer Res. 2004 Oct 1;64(19):6892-9. (PMID: 15466178)
Surg Neurol. 2005 Feb;63(2):162-9; discussion 169. (PMID: 15680662)
J Neurooncol. 1984;2(2):123-8. (PMID: 6090601)
Acta Cytol. 1981 Sep-Oct;25(5):461-79. (PMID: 7025541)
J Neurosurg. 1994 May;80(5):834-9. (PMID: 8169622)
J Clin Oncol. 2008 Mar 10;26(8):1338-45. (PMID: 18323558)
J Korean Neurosurg Soc. 2011 Jun;49(6):334-8. (PMID: 21887390)
Cancer. 2005 Mar 15;103(6):1227-33. (PMID: 15690327)
Acta Neurochir (Wien). 2001;143(1):25-9. (PMID: 11345714)
J Pathol. 1971 Apr;103(4):245-56. (PMID: 5563877)
J Neurosurg. 1978 May;48(5):747-53. (PMID: 641554)
J Clin Neurosci. 2012 Nov;19(11):1511-5. (PMID: 22595352)
Lancet. 2007 Oct 20;370(9596):1453-7. (PMID: 18064739)
J Neurooncol. 2012 Nov;110(2):221-6. (PMID: 22886532)
JAMA. 2013 Nov 6;310(17):1842-50. (PMID: 24193082)
Neurochirurgia (Stuttg). 1989 Sep;32(5):157-9. (PMID: 2552337)
Acta Neurochir (Wien). 1994;126(2-4):84-92. (PMID: 8042560)
Science. 1998 Jun 5;280(5369):1614-7. (PMID: 9616126)
Eur J Neurol. 2010 Sep;17(9):1124-33. (PMID: 20718851)
Neuro Oncol. 2013 Jan;15(1):91-6. (PMID: 23095230)
Lancet Oncol. 2014 Aug;15(9):e395-403. (PMID: 25079102)
J Neurooncol. 2011 Dec;105(3):555-62. (PMID: 21643841)
Strahlenther Onkol. 2003 Jan;179(1):8-15. (PMID: 12540979)
J Neurooncol. 2001 May;53(1):21-6. (PMID: 11678426)
Neurosurgery. 1990 Oct;27(4):516-21; discussion 521-2. (PMID: 2172859)
Ann Neurol. 1980 Dec;8(6):605-8. (PMID: 6260012)
Tumori. 2008 Jan-Feb;94(1):40-51. (PMID: 18468334)
J Neurooncol. 2003 Feb;61(3):227-35. (PMID: 12675316)
J Neurosurg. 2001 Aug;95(2):190-8. (PMID: 11780887)
J Neurosurg. 2014 Apr;120(4):833-9. (PMID: 24286144)
Int J Radiat Oncol Biol Phys. 2013 Jul 15;86(4):616-22. (PMID: 23540348)
Int J Radiat Oncol Biol Phys. 2013 Jul 15;86(4):609-15. (PMID: 23462418)
Neuro Oncol. 2014 May;16(5):719-27. (PMID: 24463354)
Neurosurgery. 1986 Aug;19(2):247-51. (PMID: 3748352)
Int J Radiat Oncol Biol Phys. 2013 Jul 15;86(4):606-8. (PMID: 23773389)
J Neurooncol. 2004 Jan;66(1-2):209-16. (PMID: 15015789)
Neuroradiol J. 2013 Oct;26(5):542-7. (PMID: 24199814)
Cancer. 1978 Dec;42(6):2854-64. (PMID: 215298)
J Neurosurg. 2003 Nov;99(5):854-62. (PMID: 14609165)
Neurosurgery. 1989 Oct;25(4):533-40. (PMID: 2797391)
Am J Clin Pathol. 2007 Apr;127(4):585-90. (PMID: 17369134)
Neuro Oncol. 2002 Apr;4(2):129-33. (PMID: 11916505)
Lancet Oncol. 2006 May;7(5):392-401. (PMID: 16648043)
J Neurooncol. 2003 Jun;63(2):191-9. (PMID: 12825824)
Radiology. 1991 Feb;178(2):467-74. (PMID: 1987610)
J Clin Neurosci. 2004 Jan;11(1):37-41. (PMID: 14642363)
Neurosurgery. 1992 Jan;30(1):64-71. (PMID: 1738457)
J Biol Chem. 1999 Jul 16;274(29):20693-703. (PMID: 10400703)
Tumour Biol. 2014 Jul;35(7):6687-93. (PMID: 24705863)
Neuro Oncol. 2008 Feb;10(1):79-87. (PMID: 17993634)
J Neurooncol. 2014 Feb;116(3):617-23. (PMID: 24401959)
Surg Neurol. 2001 Jul;56(1):33-7; discussion 37-8. (PMID: 11546569)
J Neurooncol. 1998 May;37(3):285-93. (PMID: 9524086)
Cancer Res. 2004 Oct 1;64(19):6892-9. (PMID: 15466178)
Surg Neurol. 2005 Feb;63(2):162-9; discussion 169. (PMID: 15680662)
J Neurooncol. 1984;2(2):123-8. (PMID: 6090601)
Acta Cytol. 1981 Sep-Oct;25(5):461-79. (PMID: 7025541)
J Neurosurg. 1994 May;80(5):834-9. (PMID: 8169622)
J Clin Oncol. 2008 Mar 10;26(8):1338-45. (PMID: 18323558)
J Korean Neurosurg Soc. 2011 Jun;49(6):334-8. (PMID: 21887390)
Cancer. 2005 Mar 15;103(6):1227-33. (PMID: 15690327)
Acta Neurochir (Wien). 2001;143(1):25-9. (PMID: 11345714)
J Pathol. 1971 Apr;103(4):245-56. (PMID: 5563877)
J Neurosurg. 1978 May;48(5):747-53. (PMID: 641554)
J Clin Neurosci. 2012 Nov;19(11):1511-5. (PMID: 22595352)
Lancet. 2007 Oct 20;370(9596):1453-7. (PMID: 18064739)
J Neurooncol. 2012 Nov;110(2):221-6. (PMID: 22886532)
JAMA. 2013 Nov 6;310(17):1842-50. (PMID: 24193082)
Neurochirurgia (Stuttg). 1989 Sep;32(5):157-9. (PMID: 2552337)
Acta Neurochir (Wien). 1994;126(2-4):84-92. (PMID: 8042560)
Science. 1998 Jun 5;280(5369):1614-7. (PMID: 9616126)
Eur J Neurol. 2010 Sep;17(9):1124-33. (PMID: 20718851)
Neuro Oncol. 2013 Jan;15(1):91-6. (PMID: 23095230)
Lancet Oncol. 2014 Aug;15(9):e395-403. (PMID: 25079102)
J Neurooncol. 2011 Dec;105(3):555-62. (PMID: 21643841)
Strahlenther Onkol. 2003 Jan;179(1):8-15. (PMID: 12540979)
J Neurooncol. 2001 May;53(1):21-6. (PMID: 11678426)
Neurosurgery. 1990 Oct;27(4):516-21; discussion 521-2. (PMID: 2172859)
Ann Neurol. 1980 Dec;8(6):605-8. (PMID: 6260012)
Tumori. 2008 Jan-Feb;94(1):40-51. (PMID: 18468334)
J Neurooncol. 2003 Feb;61(3):227-35. (PMID: 12675316)
J Neurosurg. 2001 Aug;95(2):190-8. (PMID: 11780887)
J Neurosurg. 2014 Apr;120(4):833-9. (PMID: 24286144)
Entry Date(s):
Date Created: 20151205 Date Completed: 20161006 Latest Revision: 20181113
Update Code:
20250114
PubMed Central ID:
PMC4669436
DOI:
10.1038/srep17758
PMID:
26635136
Database:
MEDLINE
Weitere Informationen
Leptomeningeal metastasis (LM) of high grade gliomas (HGG) can lead to devastating disease courses. Understanding of risk factors for LM is important to identify patients at risk. We reviewed patient records and magnetic resonance imaging (MRI) of all patients with a first diagnosis of HGG who underwent surgery in our institution between 2008 and 2012. To assess the influence of potential risk factors for LM and the impact of LM on survival multivariate statistics were performed. 239 patients with a diagnosis of HGG and at least 6 months of MRI and clinical follow-up were included. LM occurred in 27 (11%) patients and was symptomatic in 17 (65%). A strong correlation of surgical entry to the ventricle and LM was found (HR: 8.1). Ventricular entry was documented in 137 patients (57%) and LM ensued in 25 (18%) of these. Only two (2%) of 102 patients without ventricular entry developed LM. Median overall survival of patients after diagnosis of LM (239 days) was significantly shorter compared to patients without LM (626 days). LM is a frequent complication in the course of disease of HGG and is associated with poor survival. Surgical entry to the ventricle is a key risk factor for LM.