Treffer: Radiotherapy-related intracranial aneurysm: case presentation of a 17-year male and a meta-analysis based on individual patient data.
Title:
Radiotherapy-related intracranial aneurysm: case presentation of a 17-year male and a meta-analysis based on individual patient data.
Authors:
Wu YH; Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Public Health, National Yang-Ming University, Taipei, Taiwan., Lin SS; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Chen HH; Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan., Chang FC; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan., Liang ML; Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan., Wong TT; Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; Department of Neurosurgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan., Yen SH; Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan., Chen YW; Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan. chenyw@vghtpe.gov.tw.; School of Medicine, National Yang-Ming University, Taipei, Taiwan. chenyw@vghtpe.gov.tw.
Source:
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery [Childs Nerv Syst] 2016 Sep; Vol. 32 (9), pp. 1641-52. Date of Electronic Publication: 2016 Jun 15.
Publication Type:
Case Reports; Journal Article; Meta-Analysis
Language:
English
Journal Info:
Publisher: Springer International Country of Publication: Germany NLM ID: 8503227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-0350 (Electronic) Linking ISSN: 02567040 NLM ISO Abbreviation: Childs Nerv Syst Subsets: MEDLINE
Imprint Name(s):
Original Publication: Berlin : Springer International, c1985-
MeSH Terms:
Aneurysm, Ruptured/*diagnostic imaging , Intracranial Aneurysm/*diagnostic imaging , Radiation Injuries/*diagnostic imaging, Adolescent ; Adult ; Aneurysm, Ruptured/etiology ; Cerebral Angiography/methods ; Female ; Humans ; Intracranial Aneurysm/etiology ; Male ; Middle Aged ; Radiation Injuries/etiology ; Statistics as Topic/methods ; Young Adult
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J Neurointerv Surg. 2015 Jun;7(6):e21. (PMID: 24847091)
Int J Radiat Oncol Biol Phys. 1990 May;18(5):1001-4. (PMID: 2347709)
No Shinkei Geka. 1992 Apr;20(4):487-92. (PMID: 1570076)
Childs Nerv Syst. 2001 Feb;17(3):173-8. (PMID: 11305772)
Acta Neurochir (Wien). 2006 Dec;148(12):1317-8; discussion 1318. (PMID: 17043748)
AJNR Am J Neuroradiol. 2003 Aug;24(7):1449-52. (PMID: 12917144)
J Neurosurg. 1989 Apr;70(4):545-50. (PMID: 2926494)
J Neurosurg. 2009 Mar;110(3):543-6. (PMID: 18976052)
J Neurol Surg Rep. 2013 Dec;74(2):111-7. (PMID: 24303346)
N Engl J Med. 1993 Jan 14;328(2):87-94. (PMID: 8416438)
J Cerebrovasc Endovasc Neurosurg. 2012 Dec;14(4):300-4. (PMID: 23346546)
Acta Neurol Belg. 2010 Sep;110(3):276-8. (PMID: 21114139)
J Neurosurg Pediatr. 2011 Jun;7(6):633-6. (PMID: 21631201)
J Laryngol Otol. 1993 Feb;107(2):137-9. (PMID: 8496647)
Neurosurgery. 1997 Apr;40(4):651-62; discussion 662-3. (PMID: 9092838)
J Clin Oncol. 2012 Jan 20;30(3):246-55. (PMID: 22184380)
Surg Neurol. 2006 Apr;65(4):391-5, discussion 395-6. (PMID: 16531206)
J Neurol Surg Rep. 2014 Dec;75(2):e200-5. (PMID: 25485213)
Acta Neurochir (Wien). 2001;143(4):351-5; discussion 355-6. (PMID: 11437288)
Angiology. 1987 Feb;38(2 Pt 1):147-50. (PMID: 3826752)
J Neurosurg. 2009 Mar;110(3):540-2. (PMID: 19012483)
J Neurol Neurosurg Psychiatry. 2004 Sep;75(9):1343-5. (PMID: 15314130)
Neurol Med Chir (Tokyo). 1987 Mar;27(3):224-8. (PMID: 2442647)
J Neurooncol. 2015 May;122(3):421-9. (PMID: 25670390)
Otolaryngol Head Neck Surg. 2004 Mar;130(3):388-90. (PMID: 15054390)
Ann Otol Rhinol Laryngol. 2005 Dec;114(12):939-40. (PMID: 16425560)
Neurol Med Chir (Tokyo). 2009 May;49(5):202-5. (PMID: 19465790)
Rev Neurol (Paris). 2003 Mar;159(3):319-22. (PMID: 12703050)
Stroke. 1998 Jan;29(1):251-6. (PMID: 9445359)
Otolaryngol Head Neck Surg. 2001 Nov;125(5):522-7. (PMID: 11700454)
Neurosurgery. 2002 Apr;50(4):885-7; discussion 887-8. (PMID: 11904045)
AJNR Am J Neuroradiol. 1996 Feb;17(2):226-32. (PMID: 8938290)
Acta Neurochir Suppl. 2002;82:55-8. (PMID: 12378992)
Semin Pediatr Neurol. 2012 Mar;19(1):18-24. (PMID: 22641072)
Stroke. 2000 Aug;31(8):1843-50. (PMID: 10926945)
N Engl J Med. 2006 Aug 31;355(9):928-39. (PMID: 16943405)
J Vasc Interv Radiol. 2006 Dec;17 (12 ):1891-6. (PMID: 17185684)
J Neurosurg. 1984 Dec;61(6):1141-5. (PMID: 6502244)
Lancet Oncol. 2010 Feb;11(2):193-203. (PMID: 20152771)
Neurol Med Chir (Tokyo). 2011;51(3):226-9. (PMID: 21441741)
Aust N Z J Surg. 2000 Mar;70(3):237-8. (PMID: 10765913)
J Clin Epidemiol. 1998 Dec;51(12):1271-6. (PMID: 10086819)
N Engl J Med. 1997 Jan 2;336(1):28-40. (PMID: 8970938)
J Neurosurg. 2006 Aug;105(2 Suppl):134-9. (PMID: 16922075)
J Craniofac Surg. 2014 Jul;25(4):e380-2. (PMID: 25006955)
Circulation. 2002 Jun 11;105(23):2712-8. (PMID: 12057983)
World Neurosurg. 2014 Mar-Apr;81(3-4):492-3. (PMID: 24444793)
Radiology. 2002 Jun;223(3):683-8. (PMID: 12034935)
Stroke. 2012 Nov;43(11):3035-40. (PMID: 22968468)
Acta Neurochir (Wien). 2000;142(2):139-43. (PMID: 10795887)
JACC Cardiovasc Imaging. 2012 Apr;5(4):358-66. (PMID: 22498324)
J Korean Neurosurg Soc. 2011 Nov;50(5):457-9. (PMID: 22259694)
Pediatr Blood Cancer. 2009 Feb;52(2):227-30. (PMID: 18937328)
AJNR Am J Neuroradiol. 2001 Aug;22(7):1346-8. (PMID: 11498424)
Neuroradiology. 1994 Nov;36(8):611-3. (PMID: 7862276)
Ann Intern Med. 2009 Aug 18;151(4):264-9, W64. (PMID: 19622511)
Acta Radiol. 1997 Jan;38(1):37-42. (PMID: 9059399)
Skull Base. 2004 Aug;14(3):169-73. (PMID: 16145601)
Acta Neurochir (Wien). 1990;102(3-4):141-4. (PMID: 2336981)
N Engl J Med. 2012 Jun 28;366(26):2474-82. (PMID: 22738097)
Br J Neurosurg. 1993;7(5):575-9. (PMID: 8267898)
Clin Neurol Neurosurg. 2013 Jun;115(6):713-7. (PMID: 22910397)
Childs Nerv Syst. 2006 Jun;22(6):547-55. (PMID: 16607532)
Head Neck. 2008 Aug;30(8):1132-5. (PMID: 18213720)
World Neurosurg. 2014 Mar-Apr;81(3-4):511-9. (PMID: 24148882)
J Neurointerv Surg. 2015 Jun;7(6):e21. (PMID: 24847091)
Int J Radiat Oncol Biol Phys. 1990 May;18(5):1001-4. (PMID: 2347709)
No Shinkei Geka. 1992 Apr;20(4):487-92. (PMID: 1570076)
Childs Nerv Syst. 2001 Feb;17(3):173-8. (PMID: 11305772)
Acta Neurochir (Wien). 2006 Dec;148(12):1317-8; discussion 1318. (PMID: 17043748)
AJNR Am J Neuroradiol. 2003 Aug;24(7):1449-52. (PMID: 12917144)
J Neurosurg. 1989 Apr;70(4):545-50. (PMID: 2926494)
J Neurosurg. 2009 Mar;110(3):543-6. (PMID: 18976052)
J Neurol Surg Rep. 2013 Dec;74(2):111-7. (PMID: 24303346)
N Engl J Med. 1993 Jan 14;328(2):87-94. (PMID: 8416438)
J Cerebrovasc Endovasc Neurosurg. 2012 Dec;14(4):300-4. (PMID: 23346546)
Acta Neurol Belg. 2010 Sep;110(3):276-8. (PMID: 21114139)
J Neurosurg Pediatr. 2011 Jun;7(6):633-6. (PMID: 21631201)
Contributed Indexing:
Keywords: Aneurysm; Radiation toxicity; Radiotherapy; Vasculopathy
Entry Date(s):
Date Created: 20160617 Date Completed: 20170713 Latest Revision: 20181113
Update Code:
20250114
DOI:
10.1007/s00381-016-3144-9
PMID:
27306914
Database:
MEDLINE
Weitere Informationen
Purpose: The aim of this study was to investigate the incidence, clinical profiles, latency, and outcomes of radiotherapy (RT)-related intracranial aneurysms, rare but often fatal complications of cranial irradiation.
Methods: We reviewed all published individual patient data regardless of language, using survival analysis to make statistical inferences.
Results: We examined a total of 58 patients with RT-related intracranial aneurysms, including one unpublished case presented here, of whom 74.1 % presented with rupture. In the study, 29.3 % were younger than 18 years. The mean age at which patients received the first course of RT was 34.8 ± 22.8 years old. The mean latency between initiating RT and presenting with aneurysm was 10.4 ± 8.5 years. Rapid death ensured in 24 % shortly after presentation. The only significant predictor of death was rupture. In those with a single aneurysm, 43.1 % were located at the internal carotid artery, while 15.5 % of patients had multiple aneurysms. A male-to-female ratio of 1.87, 0.5, and 1.32 was found in patients younger than age 52, 52 years of age or older, and all 58 patients, respectively. Older age when receiving RT and presentation with ruptured aneurysm were significantly associated with shorter latency.
Conclusions: RT-related intracranial aneurysms presented differently from classical ones based on age, sex, site, multiplicity, and type. Sex ratios differed with age. The younger age group showed a longer latency of occurrence of an aneurysm. Older patients and those who develop ruptured aneurysms presented earlier. Since rupture may affect outcome, early detection of aneurysms before rupture may save lives.