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Treffer: Graphical display of histopathology data from toxicology studies for drug discovery and development: An industry perspective.

Title:
Graphical display of histopathology data from toxicology studies for drug discovery and development: An industry perspective.
Authors:
Brown AP; Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA. Electronic address: alan_p.brown@novartis.com., Drew P; PDS Consultants, Innovation Centre, 49 Oxford Street, Leicester, LE1 5XY England, UK., Knight B; Boehringer-Ingelheim, 900 Ridgebury Road, Ridgefield, CT 06877, USA., Marc P; Novartis Institutes for Biomedical Research, Basel CH-4200, Switzerland., Troth S; Merck & Co., Inc., WP81-404, Sumneytown Pike, West Point, PA 19486, USA., Wuersch K; Novartis Institutes for Biomedical Research, Basel CH-4200, Switzerland., Zandee J; Integrated Nonclinical Development Solutions (INDS) Incorporated, 6111 Jackson Road, Suite 100, Ann Arbor, MI 48103, USA.
Source:
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2016 Dec; Vol. 82, pp. 167-172. Date of Electronic Publication: 2016 Oct 18.
Publication Type:
Congress
Language:
English
Journal Info:
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8214983 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0295 (Electronic) Linking ISSN: 02732300 NLM ISO Abbreviation: Regul Toxicol Pharmacol Subsets: MEDLINE
Imprint Name(s):
Publication: <2003>- : Amsterdam : Elsevier
Original Publication: New York : Academic Press, [c1981-
MeSH Terms:
Computer Graphics* , Data Display*, Drug Discovery/*methods , Drug Industry/*methods , Pathology/*methods , Toxicity Tests/*methods, Communication ; Comprehension ; Consensus ; Humans ; Risk Assessment ; Software ; Visual Perception
Contributed Indexing:
Keywords: Graphics; Histopathology; Informatics; SEND; Toxicology
Entry Date(s):
Date Created: 20161023 Date Completed: 20170316 Latest Revision: 20181202
Update Code:
20250114
DOI:
10.1016/j.yrtph.2016.10.009
PMID:
27769829
Database:
MEDLINE

Weitere Informationen

Histopathology data comprise a critical component of pharmaceutical toxicology studies and are typically presented as finding incidence counts and severity scores per organ, and tabulated on multiple pages which can be challenging for review and aggregation of results. However, the SEND (Standard for Exchange of Nonclinical Data) standard provides a means for collecting and managing histopathology data in a uniform fashion which can allow informatics systems to archive, display and analyze data in novel ways. Various software applications have become available to convert histopathology data into graphical displays for analyses. A subgroup of the FDA-PhUSE Nonclinical Working Group conducted intra-industry surveys regarding the use of graphical displays of histopathology data. Visual cues, use-cases, the value of cross-domain and cross-study visualizations, and limitations were topics for discussion in the context of the surveys. The subgroup came to the following conclusions. Graphical displays appear advantageous as a communication tool to both pathologists and non-pathologists, and provide an efficient means for communicating pathology findings to project teams. Graphics can support hypothesis-generation which could include cross-domain interactive visualizations and/-or aggregating large datasets from multiple studies to observe and/or display patterns and trends. Incorporation of the SEND standard will provide a platform by which visualization tools will be able to aggregate, select and display information from complex and disparate datasets.
(Copyright © 2016 Elsevier Inc. All rights reserved.)