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Treffer: Mutation-Simulator: fine-grained simulation of random mutations in any genome.

Title:
Mutation-Simulator: fine-grained simulation of random mutations in any genome.
Authors:
Kühl MA; Quantitative Genetics and Genomics of Plants, Heinrich Heine University, Düsseldorf 40225, Germany., Stich B; Quantitative Genetics and Genomics of Plants, Heinrich Heine University, Düsseldorf 40225, Germany., Ries DC; Quantitative Genetics and Genomics of Plants, Heinrich Heine University, Düsseldorf 40225, Germany.
Source:
Bioinformatics (Oxford, England) [Bioinformatics] 2021 May 01; Vol. 37 (4), pp. 568-569.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
Language:
English
Journal Info:
Publisher: Oxford University Press Country of Publication: England NLM ID: 9808944 Publication Model: Print Cited Medium: Internet ISSN: 1367-4811 (Electronic) Linking ISSN: 13674803 NLM ISO Abbreviation: Bioinformatics Subsets: MEDLINE
Imprint Name(s):
Original Publication: Oxford : Oxford University Press, c1998-
MeSH Terms:
Genome* , Software*, Computer Simulation ; High-Throughput Nucleotide Sequencing ; Mutation
References:
Bioinformatics. 2017 Feb 10;33(12):1876-1878. (PMID: 28186240)
Nat Commun. 2019 Mar 27;10(1):1393. (PMID: 30918265)
Science. 2010 Jan 1;327(5961):92-4. (PMID: 20044577)
Bioinformatics. 2019 Nov 1;35(21):4442-4444. (PMID: 31116378)
BMC Bioinformatics. 2017 Sep 29;18(1):428. (PMID: 28969586)
Nat Rev Genet. 2016 Aug;17(8):459-69. (PMID: 27320129)
Entry Date(s):
Date Created: 20200812 Date Completed: 20210603 Latest Revision: 20230519
Update Code:
20250114
PubMed Central ID:
PMC8088320
DOI:
10.1093/bioinformatics/btaa716
PMID:
32780803
Database:
MEDLINE

Weitere Informationen

Summary: Mutation-Simulator allows the introduction of various types of sequence alterations in reference sequences, with reasonable compute-time even for large eukaryotic genomes. Its intuitive system for fine-grained control over mutation rates along the sequence enables the mimicking of natural mutation patterns. Using standard file formats for input and output data, it can easily be integrated into any development and benchmarking workflow for high-throughput sequencing applications.
Availability and Implementation: Mutation-Simulator is written in Python 3 and the source code, documentation, help and use cases are available on the Github page at https://github.com/mkpython3/Mutation-Simulator. It is free for use under the GPL 3 license.
(© The Author(s) 2020. Published by Oxford University Press.)