Treffer: Missed radiation therapy sessions in first three weeks predict distant metastasis and less favorable outcomes in surgically treated patients with oral cavity squamous cell carcinoma.
Title:
Missed radiation therapy sessions in first three weeks predict distant metastasis and less favorable outcomes in surgically treated patients with oral cavity squamous cell carcinoma.
Authors:
Chiang YY; Department of Radiation Oncology, Proton and Radiation Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan., Chou YC; Department of Radiation Oncology, Proton and Radiation Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan., Chang KP; Department of Otolaryngology-Head Neck Surgery, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan.; College of Medicine Chang Gung University, Taoyuan, Taiwan.; Department of Head and Neck Oncology, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan., Liao CT; Department of Otolaryngology-Head Neck Surgery, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan.; College of Medicine Chang Gung University, Taoyuan, Taiwan.; Department of Head and Neck Oncology, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan., Wu YY; Department of Radiation Oncology, Proton and Radiation Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan., Yap WK; Department of Radiation Oncology, Proton and Radiation Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan., Pai PC; Department of Radiation Oncology, Proton and Radiation Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan., Chang JT; Department of Radiation Oncology, Proton and Radiation Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan., Lin CY; Department of Radiation Oncology, Proton and Radiation Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan., Fan KH; Department of Radiation Oncology, Proton and Radiation Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan., Huang BS; Department of Radiation Oncology, Proton and Radiation Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan., Hung TM; Department of Radiation Oncology, Proton and Radiation Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan., Tsang NM; Department of Radiation Oncology, Proton and Radiation Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan. tsangrt123@gmail.com.; School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan. tsangrt123@gmail.com.; Department of Radiation Oncology, Fangliao General Hospital, No. 139, Zhongshan Rd., Fangliao Township, Pingtung County, 940, Taiwan. tsangrt123@gmail.com.; Department of Radiation Oncology, Chang Gung Memorial Hospital at Lin-Kou, School of Traditional Chinese Medicine, Chang Gung University, No. 5 Fu-Hsing Street, Kwei-Shan, Taoyuan, 333, Taiwan. tsangrt123@gmail.com.
Source:
Radiation oncology (London, England) [Radiat Oncol] 2020 Aug 14; Vol. 15 (1), pp. 194. Date of Electronic Publication: 2020 Aug 14.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: BioMed Central Country of Publication: England NLM ID: 101265111 Publication Model: Electronic Cited Medium: Internet ISSN: 1748-717X (Electronic) Linking ISSN: 1748717X NLM ISO Abbreviation: Radiat Oncol Subsets: MEDLINE
Imprint Name(s):
Original Publication: [London] : BioMed Central, 2006-
MeSH Terms:
Carcinoma, Squamous Cell/*secondary , Mouth Neoplasms/*pathology , Neoplasm Recurrence, Local/*pathology , Patient Compliance/*statistics & numerical data , Radiotherapy, Adjuvant/*mortality, Carcinoma, Squamous Cell/radiotherapy ; Female ; Humans ; Male ; Middle Aged ; Mouth Neoplasms/radiotherapy ; Neoplasm Recurrence, Local/radiotherapy ; Patient Compliance/psychology ; Prognosis ; Retrospective Studies ; Survival Rate
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Int J Radiat Oncol Biol Phys. 2016 Dec 1;96(5):967-975. (PMID: 27869097)
Cancer. 2004 Oct 15;101(8):1818-23. (PMID: 15386306)
Radiother Oncol. 2019 Mar;132:178-187. (PMID: 30448002)
Mol Med. 2018 Apr 24;24(1):16. (PMID: 30134800)
Int J Radiat Oncol Biol Phys. 2002 Sep 1;54(1):229-36. (PMID: 12182996)
JAMA Otolaryngol Head Neck Surg. 2018 Apr 1;144(4):349-359. (PMID: 29522072)
CA Cancer J Clin. 2018 Nov;68(6):394-424. (PMID: 30207593)
Int J Radiat Oncol Biol Phys. 2001 Nov 1;51(3):571-8. (PMID: 11597795)
Radiother Oncol. 1998 Aug;48(2):165-73. (PMID: 9783888)
Jpn J Clin Oncol. 2016 Oct;46(10):919-927. (PMID: 27511989)
Nat Cell Biol. 2018 Sep;20(9):1084-1097. (PMID: 30154549)
Rep Pract Oncol Radiother. 2015 Sep-Oct;20(5):328-39. (PMID: 26549990)
Int J Radiat Oncol Biol Phys. 2003 Jun 1;56(2):399-412. (PMID: 12738315)
Int J Radiat Oncol Biol Phys. 2017 Aug 1;98(5):1002-1011. (PMID: 28721881)
Int J Radiat Oncol Biol Phys. 2007 Apr 1;67(5):1332-41. (PMID: 17276613)
Oral Oncol. 2018 Nov;86:188-194. (PMID: 30409299)
Adv Radiat Oncol. 2017 Oct 23;3(1):62-69. (PMID: 29556582)
JAMA Otolaryngol Head Neck Surg. 2019 Feb 1;145(2):166-177. (PMID: 30383146)
Int J Radiat Oncol Biol Phys. 2007 Jul 1;68(3):654-61. (PMID: 17467926)
J Chronic Dis. 1987;40(5):373-83. (PMID: 3558716)
Radiother Oncol. 2011 Jul;100(1):33-40. (PMID: 21684027)
Oncol Lett. 2019 Jan;17(1):1384-1390. (PMID: 30655910)
Int J Radiat Oncol Biol Phys. 2012 Dec 1;84(5):1198-205. (PMID: 22749632)
Int J Radiat Oncol Biol Phys. 2011 Aug 1;80(5):1412-22. (PMID: 20675073)
Radiother Oncol. 1994 Feb;30(2):109-20. (PMID: 8184108)
J Nucl Med. 2015 Jan;56(1):22-30. (PMID: 25525186)
Cancer Med. 2018 Jun 14;:. (PMID: 29905028)
Cancer. 2017 Dec 15;123(24):4841-4850. (PMID: 28841234)
Nature. 2016 Dec 22;540(7634):552-558. (PMID: 27974799)
MMWR Morb Mortal Wkly Rep. 2016 Oct 07;65(39):1045-1051. (PMID: 27711031)
Onco Targets Ther. 2015 Jan 28;8:251-8. (PMID: 25670907)
Radiother Oncol. 2015 Apr;115(1):56-62. (PMID: 25792467)
Radiat Oncol. 2014 Mar 23;9:81. (PMID: 24655942)
Grant Information:
BMRP 238, CMRPG3H1221, and CMRPG3H1851 Chang Gung Memorial Hospital, Linkou
Contributed Indexing:
Keywords: Distant metastasis; Missed sessions; Oral cavity cancer; Overall survival; Prognosis; Radiation therapy; Squamous cell carcinoma
Entry Date(s):
Date Created: 20200816 Date Completed: 20210608 Latest Revision: 20210608
Update Code:
20250114
PubMed Central ID:
PMC7427928
DOI:
10.1186/s13014-020-01632-1
PMID:
32795324
Database:
MEDLINE
Weitere Informationen
Background: We sought to investigate the prognostic impact of missed RT sessions in patients who had undergone surgery for oral cavity squamous cell carcinoma (OCSCC).
Methods: The study sample consisted of 905 patients with surgically treated OCSCC who fulfilled criteria of RT course ≤8 weeks. The study participants were divided into three groups based on the characteristics of missed RT, as follows: 1) early missed RT, 2) late missed RT, and 3) RT as scheduled.
Results: The 5-year overall survival (OS) rates in the early missed RT, late missed RT, and RT as scheduled groups were 53.0, 58.1, and 64.5%, respectively (p = 0.046). In multivariate analysis, early missed RT was independently associated with both OS (hazard ratio (HR) = 1.486; 95% confidence interval (CI): 1.122-1.966; p = 0.006) and the occurrence of distant metastasis (HR = 1.644; 95% CI: 1.047-2.583; p = 0.031).
Conclusion: Early missed RT was independently associated with a higher occurrence of distant metastasis and less favorable OS in patients who had undergone surgery for OCSCC.