Treffer: Multivariate Neural Connectivity Patterns in Early Infancy Predict Later Autism Symptoms.
Title:
Multivariate Neural Connectivity Patterns in Early Infancy Predict Later Autism Symptoms.
Authors:
Dickinson A; Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California. Electronic address: adickinson@mednet.ucla.edu., Daniel M; Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California., Marin A; Department of Psychology, University of California, San Diego, San Diego, California., Gaonkar B; Department of Neurosurgery, Ronald Reagan UCLA Medical Center, University of California, Los Angeles, California., Dapretto M; Ahmanson-Lovelace Brain Mapping Center, University of California, Los Angeles, Los Angeles, California., McDonald NM; Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California., Jeste S; Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California.
Source:
Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2021 Jan; Vol. 6 (1), pp. 59-69. Date of Electronic Publication: 2020 Jun 13.
Publication Type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Language:
English
Journal Info:
Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 101671285 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9030 (Electronic) Linking ISSN: 24519022 NLM ISO Abbreviation: Biol Psychiatry Cogn Neurosci Neuroimaging Subsets: MEDLINE
Imprint Name(s):
Original Publication: New York, NY : Elsevier, Inc., [2016]-
MeSH Terms:
References:
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Brain Res. 2012 May 25;1456:72-81. (PMID: 22516109)
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Autism Res. 2017 Jan;10(1):169-178. (PMID: 27417857)
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Int J Speech Lang Pathol. 2014 Feb;16(1):36-42. (PMID: 24410019)
Neuroscientist. 2006 Oct;12(5):435-41. (PMID: 16957005)
Dev Rev. 2018 Jun;48:113-144. (PMID: 30270962)
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J Autism Dev Disord. 2000 Jun;30(3):205-23. (PMID: 11055457)
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Cereb Cortex. 2007 Apr;17(4):951-61. (PMID: 16772313)
Nat Rev Genet. 2015 Aug;16(8):441-58. (PMID: 26149713)
Psychophysiology. 2012 Nov;49(11):1617-21. (PMID: 23013047)
Biol Psychiatry. 2011 Dec 15;70(12):1134-42. (PMID: 21861988)
Neuroimage. 2011 Jun 1;56(3):1832-8. (PMID: 21356316)
Cereb Cortex. 2018 Apr 1;28(4):1141-1153. (PMID: 28184409)
Neuropsychologia. 2006;44(4):610-21. (PMID: 16140346)
JAMA. 2011 Nov 9;306(18):2001-10. (PMID: 22068992)
Child Dev. 1992 Oct;63(5):1142-63. (PMID: 1446545)
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J Child Psychol Psychiatry. 2010 Apr;51(4):432-58. (PMID: 20085609)
Science. 2010 Sep 10;329(5997):1358-61. (PMID: 20829489)
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Autism Res. 2017 May;10(5):961-972. (PMID: 28244271)
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J Am Acad Child Adolesc Psychiatry. 2017 Apr;56(4):313-320. (PMID: 28335875)
Psychiatry Res Neuroimaging. 2019 Jan 30;283:83-91. (PMID: 30557783)
Cell. 2013 Nov 21;155(5):997-1007. (PMID: 24267886)
Neuroimage. 2003 Aug;19(4):1835-42. (PMID: 12948738)
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J Neurosci. 2011 Apr 27;31(17):6405-13. (PMID: 21525281)
Pediatrics. 2015 Oct;136 Suppl 1:S60-81. (PMID: 26430170)
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:1242-1245. (PMID: 30440615)
Neuropsychopharmacology. 2008 Jan;33(1):181-97. (PMID: 17851542)
Cell Rep. 2019 May 28;27(9):2567-2578.e6. (PMID: 31141683)
N Engl J Med. 2014 Mar 27;370(13):1209-1219. (PMID: 24670167)
Curr Opin Neurobiol. 2005 Apr;15(2):225-30. (PMID: 15831407)
Nat Neurosci. 2019 Feb;22(2):243-255. (PMID: 30617258)
Neuroimage. 2019 Jun;193:35-45. (PMID: 30831310)
Neuroimage. 2014 Oct 1;99:342-56. (PMID: 24862070)
Sci Transl Med. 2017 Jun 7;9(393):. (PMID: 28592562)
J Autism Dev Disord. 2021 Mar;51(3):798-803. (PMID: 30302595)
J Comput Biol. 2009 May;16(5):677-90. (PMID: 19432538)
Front Hum Neurosci. 2012 Aug 13;6:233. (PMID: 22905026)
Neuron. 2008 May 8;58(3):429-41. (PMID: 18466752)
J Child Psychol Psychiatry. 2002 Sep;43(6):807-21. (PMID: 12236615)
J Abnorm Psychol. 2019 Jan;128(1):69-80. (PMID: 30628809)
Autism Res. 2014 Jun;7(3):334-43. (PMID: 24623657)
Harv Rev Psychiatry. 2015 Jul-Aug;23(4):223-44. (PMID: 26146755)
Nature. 2013 Dec 19;504(7480):427-31. (PMID: 24196715)
Inf Process Med Imaging. 2003 Jul;18:330-41. (PMID: 15344469)
J Neurosci. 2017 Aug 23;37(34):8227-8238. (PMID: 28743724)
Mol Autism. 2015 Oct 27;6:59. (PMID: 26512314)
Ment Retard Dev Disabil Res Rev. 2007;13(2):129-35. (PMID: 17563895)
Neuroimage Clin. 2015 May 21;8:583-93. (PMID: 26199870)
Int J Psychophysiol. 2000 Dec 1;38(3):301-13. (PMID: 11102669)
Behav Brain Res. 2018 Aug 1;348:227-234. (PMID: 29689375)
Neuroimage. 2014 Feb 15;87:96-110. (PMID: 24239590)
Proc Biol Sci. 2015 Jun 7;282(1808):20150563. (PMID: 25972469)
Infant Behav Dev. 2019 Feb;54:37-47. (PMID: 30557704)
Science. 2017 Feb 3;355(6324):483-485. (PMID: 28154050)
Nat Rev Neurosci. 2001 Apr;2(4):229-39. (PMID: 11283746)
Neuropsychologia. 2011 Apr;49(5):1378-1382. (PMID: 21333661)
Acta Neuropathol. 2006 Sep;112(3):287-303. (PMID: 16819561)
J Neurosci Methods. 2007 Oct 15;166(1):41-52. (PMID: 17698205)
Soc Cogn Affect Neurosci. 2015 Oct;10(10):1348-56. (PMID: 25698698)
Annu Rev Neurosci. 2001;24:167-202. (PMID: 11283309)
J Autism Dev Disord. 2009 Feb;39(2):223-30. (PMID: 18821008)
J Autism Dev Disord. 2009 Sep;39(9):1305-20. (PMID: 19415479)
Electroencephalogr Clin Neurophysiol Suppl. 1999;52:3-6. (PMID: 10590970)
IEEE Trans Biomed Eng. 2015 Nov;62(11):2553-67. (PMID: 26415149)
Dev Neuropsychol. 2012;37(6):476-96. (PMID: 22889341)
Annu Rev Psychol. 2009;60:693-716. (PMID: 18771388)
Nat Protoc. 2017 Mar;12(3):506-518. (PMID: 28182017)
Nat Rev Neurosci. 2015 Sep;16(9):551-63. (PMID: 26289574)
PLoS One. 2012;7(5):e36896. (PMID: 22615837)
Res Dev Disabil. 2007 May-Jun;28(3):287-303. (PMID: 16730944)
Brain. 2015 Jul;138(Pt 7):2034-45. (PMID: 25935724)
Brain. 2018 Jul 1;141(7):2055-2065. (PMID: 29722793)
J Neurosci. 2010 Nov 3;30(44):14595-609. (PMID: 21048117)
Soc Cogn Affect Neurosci. 2013 Aug;8(6):694-701. (PMID: 22563003)
PLoS One. 2017 May 3;12(5):e0175870. (PMID: 28467487)
Electroencephalogr Clin Neurophysiol. 1997 Nov;103(5):499-515. (PMID: 9402881)
Eur J Neurosci. 2007 Feb;25(4):909-19. (PMID: 17331189)
Nat Rev Neurosci. 2014 Oct;15(10):683-95. (PMID: 25186238)
Brain. 2015 Jul;138(Pt 7):2046-58. (PMID: 25937563)
Neuroimage. 2017 Nov 1;161:251-260. (PMID: 28842386)
Curr Opin Neurobiol. 2007 Feb;17(1):103-11. (PMID: 17275283)
Neuron. 2018 Oct 24;100(2):406-423. (PMID: 30359605)
Proc Natl Acad Sci U S A. 2012 Oct 16;109 Suppl 2:17261-5. (PMID: 23045661)
Brain. 2012 May;135(Pt 5):1498-507. (PMID: 22418737)
Front Cell Neurosci. 2014 Dec 08;8:414. (PMID: 25538564)
Clin Neurophysiol. 2007 Aug;118(8):1877-88. (PMID: 17574912)
J Neurodev Disord. 2017 Sep 13;9(1):34. (PMID: 28903722)
Res Autism Spectr Disord. 2019 Jan;57:132-144. (PMID: 31223334)
Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 2):2608-20. (PMID: 23999082)
Neuroreport. 2006 Nov 6;17(16):1687-90. (PMID: 17047454)
Cereb Cortex. 2015 Nov;25(11):4596-609. (PMID: 26048954)
J Neurosci. 2019 Jul 3;39(27):5299-5310. (PMID: 31061091)
Sci Transl Med. 2010 Nov 3;2(56):56ra80. (PMID: 21048216)
J Neurosci Methods. 2004 Mar 15;134(1):9-21. (PMID: 15102499)
Neuroimage. 2005 Apr 15;25(3):916-25. (PMID: 15808991)
Grant Information:
P50 HD055784 United States HD NICHD NIH HHS; P50 HD103557 United States HD NICHD NIH HHS
Contributed Indexing:
Keywords: Autism spectrum disorder; Electroencephalography; Functional connectivity; Infancy; Machine learning; Prediction
Substance Nomenclature:
0 (Biomarkers)
Entry Date(s):
Date Created: 20200817 Date Completed: 20210603 Latest Revision: 20240330
Update Code:
20250114
PubMed Central ID:
PMC7736067
DOI:
10.1016/j.bpsc.2020.06.003
PMID:
32798139
Database:
MEDLINE
Weitere Informationen
Background: Functional brain connectivity is altered in children and adults with autism spectrum disorder (ASD). Functional disruption during infancy could provide earlier markers of ASD, thus providing a crucial opportunity to improve developmental outcomes. Using a whole-brain multivariate approach, we asked whether electroencephalography measures of neural connectivity at 3 months of age predict autism symptoms at 18 months.
Methods: Spontaneous electroencephalography data were collected from 65 infants with and without familial risk for ASD at 3 months of age. Neural connectivity patterns were quantified using phase coherence in the alpha range (6-12 Hz). Support vector regression analysis was used to predict ASD symptoms at age 18 months, with ASD symptoms quantified by the Toddler Module of the Autism Diagnostic Observation Schedule, Second Edition.
Results: Autism Diagnostic Observation Schedule scores predicted by support vector regression algorithms trained on 3-month electroencephalography data correlated highly with Autism Diagnostic Observation Schedule scores measured at 18 months (r = .76, p = .02, root-mean-square error = 2.38). Specifically, lower frontal connectivity and higher right temporoparietal connectivity at 3 months predicted higher ASD symptoms at 18 months. The support vector regression model did not predict cognitive abilities at 18 months (r = .15, p = .36), suggesting specificity of these brain patterns to ASD.
Conclusions: Using a data-driven, unbiased analytic approach, neural connectivity across frontal and temporoparietal regions at 3 months predicted ASD symptoms at 18 months. Identifying early neural differences that precede an ASD diagnosis could promote closer monitoring of infants who show signs of neural risk and provide a crucial opportunity to mediate outcomes through early intervention.
(Copyright © 2020 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)