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Treffer: Maternal and neonatal risk factors for neonatal respiratory distress syndrome in term neonates in Cyprus: a prospective case-control study.

Title:
Maternal and neonatal risk factors for neonatal respiratory distress syndrome in term neonates in Cyprus: a prospective case-control study.
Authors:
Stylianou-Riga P; Neonatal Intensive Care Unit, 'Archbishop Makarios III' Hospital, Nicosia, Cyprus. riga.paraskevi@ucy.ac.cy.; Respiratory Physiology Laboratory, Medical School, University of Cyprus, 2029 Aglantzia, Nicosia, Cyprus. riga.paraskevi@ucy.ac.cy.; Neonatal Department, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. riga.paraskevi@ucy.ac.cy., Boutsikou T; Neonatal Department, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Kouis P; Respiratory Physiology Laboratory, Medical School, University of Cyprus, 2029 Aglantzia, Nicosia, Cyprus., Kinni P; Respiratory Physiology Laboratory, Medical School, University of Cyprus, 2029 Aglantzia, Nicosia, Cyprus., Krokou M; Respiratory Physiology Laboratory, Medical School, University of Cyprus, 2029 Aglantzia, Nicosia, Cyprus., Ioannou A; Respiratory Physiology Laboratory, Medical School, University of Cyprus, 2029 Aglantzia, Nicosia, Cyprus., Siahanidou T; Neonatal Unit, First Department of Pediatrics, 'Aghia Sophia' Children's Hospital, Athens, Greece., Iliodromiti Z; Neonatal Department, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Papadouri T; Neonatal Intensive Care Unit, 'Archbishop Makarios III' Hospital, Nicosia, Cyprus., Yiallouros PK; Respiratory Physiology Laboratory, Medical School, University of Cyprus, 2029 Aglantzia, Nicosia, Cyprus., Iacovidou N; Neonatal Department, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Source:
Italian journal of pediatrics [Ital J Pediatr] 2021 Jun 03; Vol. 47 (1), pp. 129. Date of Electronic Publication: 2021 Jun 03.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: BioMed Central Country of Publication: England NLM ID: 101510759 Publication Model: Electronic Cited Medium: Internet ISSN: 1824-7288 (Electronic) Linking ISSN: 17208424 NLM ISO Abbreviation: Ital J Pediatr Subsets: MEDLINE
Imprint Name(s):
Original Publication: London : BioMed Central
MeSH Terms:
Respiratory Distress Syndrome, Newborn/*epidemiology, Case-Control Studies ; Cesarean Section/statistics & numerical data ; Cyprus/epidemiology ; Female ; Humans ; Infant, Newborn ; Male ; Pregnancy ; Prospective Studies ; Pulmonary Surfactants/administration & dosage ; Risk Factors ; Sex Factors ; Term Birth
References:
J Clin Diagn Res. 2017 Aug;11(8):SC09-SC12. (PMID: 28969229)
Pediatr Res. 2009 Nov;66(5):539-44. (PMID: 19680165)
Biomed Res Int. 2018 Oct 4;2018:7162478. (PMID: 30402491)
Chin Med J (Engl). 2010 Oct;123(19):2640-4. (PMID: 21034645)
Cochrane Database Syst Rev. 2012 Feb 15;(2):CD008155. (PMID: 22336836)
F1000Res. 2018 May 18;7:. (PMID: 29904575)
Zhonghua Er Ke Za Zhi. 2009 Sep;47(9):658-61. (PMID: 20021786)
J Matern Fetal Neonatal Med. 2017 Jun;30(11):1267-1272. (PMID: 27399933)
J Nepal Health Res Counc. 2018 Jul 03;16(2):131-135. (PMID: 29983424)
Cochrane Database Syst Rev. 2020 Apr 8;4:CD013141. (PMID: 32266712)
Paediatr Perinat Epidemiol. 2008 Jan;22(1):22-30. (PMID: 18173781)
J Lipid Res. 2006 Oct;47(10):2314-24. (PMID: 16868337)
Am J Physiol Lung Cell Mol Physiol. 2004 Jun;286(6):L1293-301. (PMID: 14742307)
Semin Perinatol. 2014 Mar;38(2):78-91. (PMID: 24580763)
Am J Respir Cell Mol Biol. 2001 Jul;25(1):45-50. (PMID: 11472974)
Early Hum Dev. 2012 May;88 Suppl 2:S69-74. (PMID: 22633519)
Front Pediatr. 2014 Jul 25;2:78. (PMID: 25121078)
BMC Pregnancy Childbirth. 2018 May 8;18(1):140. (PMID: 29739452)
Obstet Gynecol. 2016 Apr;127(4):657-666. (PMID: 26959207)
Ann Glob Health. 2020 Feb 26;86(1):22. (PMID: 32140431)
Chin Med J (Engl). 2010 Oct;123(20):2776-80. (PMID: 21034581)
BMJ. 2008 Jan 12;336(7635):85-7. (PMID: 18077440)
J Perinat Med. 2002;30(3):225-30. (PMID: 12122904)
Endocrinology. 2000 Aug;141(8):2923-9. (PMID: 10919280)
Clin Perinatol. 2008 Jun;35(2):373-93, vii. (PMID: 18456075)
Early Hum Dev. 2001 Jan;60(3):215-24. (PMID: 11146240)
Pan Afr Med J. 2016 Apr 15;23:197. (PMID: 27347286)
Pediatr Rev. 2014 Oct;35(10):417-28; quiz 429. (PMID: 25274969)
J Matern Fetal Neonatal Med. 2018 May;31(10):1373-1380. (PMID: 28372507)
Cochrane Database Syst Rev. 2017 Oct 17;10:CD003666. (PMID: 29039883)
Eur J Epidemiol. 2018 Mar;33(3):313-321. (PMID: 28887607)
PLoS One. 2018 Mar 28;13(3):e0193807. (PMID: 29590143)
Eur J Pediatr. 2017 Aug;176(8):1083-1088. (PMID: 28660312)
Int J Pediatr Adolesc Med. 2020 Mar;7(1):13-18. (PMID: 32373697)
Clin Perinatol. 2014 Jun;41(2):331-45. (PMID: 24873836)
Pediatr Infect Dis J. 2014 Oct;33(10):1027-32. (PMID: 24776516)
Pediatrics. 2000 Nov;106(5):957-64; discussion 1135. (PMID: 11061760)
Arch Gynecol Obstet. 2017 Dec;296(6):1071-1077. (PMID: 28948345)
Ital J Pediatr. 2014 Jun 03;40:52. (PMID: 24893787)
Eur J Obstet Gynecol Reprod Biol. 2001 Sep;98(1):9-13. (PMID: 11516792)
Paediatr Child Health. 2014 Apr;19(4):213-22. (PMID: 24855419)
Neonatology. 2019;115(4):432-450. (PMID: 30974433)
J Perinatol. 2012 Oct;32(10):780-5. (PMID: 22222548)
Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L559-67. (PMID: 19525387)
Pediatr Neonatol. 2018 Feb;59(1):15-23. (PMID: 28923474)
J Pediatr. 1998 Jan;132(1):40-7. (PMID: 9469998)
J Biol Chem. 1987 Jun 5;262(16):7908-13. (PMID: 3495535)
J Trop Pediatr. 1997 Jun;43(3):143-8. (PMID: 9231633)
Traffic. 2007 Dec;8(12):1765-77. (PMID: 17897321)
Early Hum Dev. 2009 Jun;85(6):353-9. (PMID: 19186013)
N Engl J Med. 2009 Jan 8;360(2):111-20. (PMID: 19129525)
Balkan Med J. 2014 Mar;31(1):64-8. (PMID: 25207170)
Aust N Z J Obstet Gynaecol. 2014 Aug;54(4):340-7. (PMID: 24836174)
Sci Rep. 2017 Aug 18;7(1):8736. (PMID: 28821800)
J Obstet Gynaecol Res. 2016 Aug;42(8):936-43. (PMID: 27079277)
J Perinatol. 2011 Sep;31(9):575-85. (PMID: 21760587)
Can Respir J. 2018 Aug 13;2018:7472964. (PMID: 30186538)
Clin Perinatol. 2010 Jun;37(2):439-79. (PMID: 20569817)
Chin Med J (Engl). 2010 Oct;123(20):2769-75. (PMID: 21034580)
J Pediatr. 2016 May;172:69-74.e2. (PMID: 26935785)
Ultrasound. 2017 May;25(2):80-91. (PMID: 28567102)
Pan Afr Med J. 2016 Jun 21;24:152. (PMID: 27642489)
Trends Endocrinol Metab. 2010 Dec;21(12):729-38. (PMID: 20971653)
Med Arch. 2019 Jun;73(3):183-186. (PMID: 31402802)
Arch Med Sci. 2011 Jun;7(3):381-7. (PMID: 22295020)
Contributed Indexing:
Keywords: Caesarean section; Maternal risk factors; Neonatal respiratory distress syndrome; Neonatal risk factors
Substance Nomenclature:
0 (Pulmonary Surfactants)
Entry Date(s):
Date Created: 20210604 Date Completed: 20211122 Latest Revision: 20211122
Update Code:
20250114
PubMed Central ID:
PMC8176707
DOI:
10.1186/s13052-021-01086-5
PMID:
34082803
Database:
MEDLINE

Weitere Informationen

Background: Neonatal respiratory distress syndrome (NRDS) is strongly associated with premature birth, but it can also affect term neonates. Unlike the extent of research in preterm neonates, risk factors associated with incidence and severity of NRDS in term neonates are not well studied. In this study, we examined the association of maternal and neonatal risk factors with the incidence and severity of NRDS in term neonates admitted to Neonatal Intensive Care Unit (NICU) in Cyprus.
Methods: In a prospective, case-control design we recruited term neonates with NRDS and non-NRDS admitted to the NICU of Archbishop Makarios III hospital, the only neonatal tertiary centre in Cyprus, between April 2017-October 2018. Clinical data were obtained from patients' files. We used univariate and multivariate logistic and linear regression models to analyse binary and continuous outcomes respectively.
Results: During the 18-month study period, 134 term neonates admitted to NICU were recruited, 55 (41%) with NRDS diagnosis and 79 with non-NRDS as controls. In multivariate adjusted analysis, male gender (OR: 4.35, 95% CI: 1.03-18.39, p = 0.045) and elective caesarean section (OR: 11.92, 95% CI: 1.80-78.95, p = 0.01) were identified as independent predictors of NRDS. Among neonates with NRDS, early-onset infection tended to be associated with increased administration of surfactant (β:0.75, 95% CI: - 0.02-1.52, p = 0.055). Incidence of pulmonary hypertension or systemic hypotension were associated with longer duration of parenteral nutrition (pulmonary hypertension: 11Vs 5 days, p < 0.001, systemic hypotension: 7 Vs 4 days, p = 0.01) and higher rate of blood transfusion (pulmonary hypertension: 100% Vs 67%, p = 0.045, systemic hypotension: 85% Vs 55%, p = 0.013).
Conclusions: This study highlights the role of elective caesarean section and male gender as independent risk factors for NRDS in term neonates. Certain therapeutic interventions are associated with complications during the course of disease. These findings can inform the development of evidence-based recommendations for improved perinatal care.