Treffer: Alcohol dependence severity determines the course of treatment-seeking patients.
Title:
Alcohol dependence severity determines the course of treatment-seeking patients.
Authors:
Yoshimura A; National Hospital Organization, Kurihama Medical and Addiction Center, Yokosuka, Japan.; Division of Psychiatry, Tohoku Medical and Pharmaceutical University, Sendai, Japan., Kimura M; National Hospital Organization, Kurihama Medical and Addiction Center, Yokosuka, Japan., Matsushita S; National Hospital Organization, Kurihama Medical and Addiction Center, Yokosuka, Japan., Yoneda JI; National Hospital Organization, Kurihama Medical and Addiction Center, Yokosuka, Japan., Maesato H; National Hospital Organization, Kurihama Medical and Addiction Center, Yokosuka, Japan., Komoto Y; Yoshino Hospital, Machida, Japan., Nakayama H; National Hospital Organization, Kurihama Medical and Addiction Center, Yokosuka, Japan.; Hokujinkai Asahiyama Hospital, Sapporo, Japan., Sakuma H; National Hospital Organization, Kurihama Medical and Addiction Center, Yokosuka, Japan., Yumoto Y; National Hospital Organization, Kurihama Medical and Addiction Center, Yokosuka, Japan., Takimura T; National Hospital Organization, Kurihama Medical and Addiction Center, Yokosuka, Japan., Tohyama T; National Hospital Organization, Kurihama Medical and Addiction Center, Yokosuka, Japan., Iwahara C; National Hospital Organization, Kurihama Medical and Addiction Center, Yokosuka, Japan., Mizukami T; National Hospital Organization, Kurihama Medical and Addiction Center, Yokosuka, Japan., Yokoyama A; National Hospital Organization, Kurihama Medical and Addiction Center, Yokosuka, Japan., Higuchi S; National Hospital Organization, Kurihama Medical and Addiction Center, Yokosuka, Japan.
Source:
Alcoholism, clinical and experimental research [Alcohol Clin Exp Res] 2021 Nov; Vol. 45 (11), pp. 2335-2346. Date of Electronic Publication: 2021 Sep 29.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
Language:
English
Journal Info:
Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7707242 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0277 (Electronic) Linking ISSN: 01456008 NLM ISO Abbreviation: Alcohol Clin Exp Res Subsets: MEDLINE
Imprint Name(s):
Publication: Oxford, UK : Wiley-Blackwell
Original Publication: New York, N.Y. : Grune & Stratton, c1977-
Original Publication: New York, N.Y. : Grune & Stratton, c1977-
MeSH Terms:
Severity of Illness Index*, Alcoholism/*therapy , Patient Acceptance of Health Care/*psychology , Temperance/*psychology, Adaptation, Psychological ; Adult ; Alcoholism/psychology ; Female ; Humans ; Male ; Middle Aged ; Motivational Interviewing/methods ; Patient Acceptance of Health Care/statistics & numerical data ; Prospective Studies ; Recurrence ; Treatment Outcome
References:
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American Psychiatric Association. (2013) Diagnostic and statistical manual of mental disorders, 5th edition. DSM-5. Washington, D.C.: American Psychiatric Publishing, Inc.
Andresen-Streichert, H., Muller, A., Glahn, A., Skopp, G. & Sterneck, M. (2018) Alcohol biomarkers in clinical and forensic contexts. Deutsches Ärzteblatt International, 115, 309-315.
Babor, T.F., Steinberg, K., Anton, R. & Del Boca, F. (2000) Talk is cheap: measuring drinking outcomes in clinical trials. Journal of Studies on Alcohol, 61, 55-63.
Boschloo, L., Vogelzangs, N., Van Den Brink, W., Smit, J.H., Beekman, A.T. & Penninx, B.W. (2012a) Predictors of the 2-year recurrence and persistence of alcohol dependence. Addiction, 107, 1639-1640.
Boschloo, L., Vogelzangs, N., Van Den Brink, W., Smit, J.H., Veltman, D.J., Beekman, A.T. et al. (2012b) Alcohol use disorders and the course of depressive and anxiety disorders. British Journal of Psychiatry, 200, 476-484.
Bottlender, M. & Soyka, M. (2005) Efficacy of an intensive outpatient rehabilitation program in alcoholism: predictors of outcome 6 months after treatment. European Addiction Research, 11, 132-137.
Chantarujikapong, S.I., Smith, E.M. & Fox, L.W. (1997) Comparison of the Alcohol Dependence Scale and diagnostic interview schedule in homeless women. Alcoholism, Clinical and Experimental Research, 21, 586-595.
Chiappetta, V., Garcia-Rodriguez, O., Jin, C.J., Secades-Villa, R. & Blanco, C. (2014) Predictors of quit attempts and successful quit attempts among individuals with alcohol use disorders in a nationally representative sample. Drug and Alcohol Dependence, 141, 138-144.
Connolly, J.M., Kavanagh, D.J., Baker, A.L., Kay-Lambkin, F.J., Lewin, T.J., Davis, P.J. et al. (2013) Craving as a predictor of treatment outcomes in heavy drinkers with comorbid depressed mood. Addictive Behaviors, 38, 1585-1592.
Dawson, D.A., Goldstein, R.B. & Grant, B.F. (2007) Rates and correlates of relapse among individuals in remission from DSM-IV alcohol dependence: a 3-year follow-up. Alcoholism, Clinical and Experimental Research, 31, 2036-2045.
Dawson, D.A., Goldstein, R.B., Ruan, W.J. & Grant, B.F. (2012) Correlates of recovery from alcohol dependence: a prospective study over a 3-year follow-up interval. Alcoholism, Clinical and Experimental Research, 36, 1268-1277.
Dawson, D.A., Grant, B.F., Stinson, F.S., Chou, P.S., Huang, B. & Ruan, W.J. (2005) Recovery from DSM-IV alcohol dependence: United States, 2001-2002. Addiction, 100, 281-292.
Hasin, D.S., Liu, X., Alderson, D. & Grant, B.F. (2006) DSM-IV alcohol dependence: a categorical or dimensional phenotype? Psychological Medicine, 36, 1695-1705.
Haug, S. & Schaub, M.P. (2016) Treatment outcome, treatment retention, and their predictors among clients of five outpatient alcohol treatment centres in Switzerland. BMC Public Health, 16, 581.
Langenbucher, J., Sulesund, D., Chung, T. & Morgenstern, J. (1996) Illness severity and self-efficacy as course predictors of DSM-IV alcohol dependence in a multisite clinical sample. Addictive Behaviors, 21, 543-553.
Mann, K., Schafer, D.R., Langle, G., Ackermann, K. & Croissant, B. (2005) The long-term course of alcoholism, 5, 10 and 16 years after treatment. Addiction, 100, 797-805.
Mclellan, A.T., Luborsky, L., Woody, G.E., Obrien, C.P. & Druley, K.A. (1983) Predicting response to alcohol and drug abuse treatments. Role of psychiatric severity. Archives of General Psychiatry, 40, 620-625.
Molander, R.C., Yonker, J.A. & Krahn, D.D. (2010) Age-related changes in drinking patterns from mid- to older age: results from the Wisconsin longitudinal study. Alcoholism, Clinical and Experimental Research, 34, 1182-1192.
Moos, R.H. & Moos, B.S. (2006) Rates and predictors of relapse after natural and treated remission from alcohol use disorders. Addiction, 101, 212-222.
Osaki, Y., Kinjo, A., Higuchi, S., Matsumoto, H., Yuzuriha, T., Horie, Y. et al. (2016) Prevalence and trends in alcohol dependence and alcohol use disorders in Japanese adults; results from periodical nationwide surveys. Alcohol and Alcoholism, 51, 465-473.
Oslin, D.W., Pettinati, H. & Volpicelli, J.R. (2002) Alcoholism treatment adherence: older age predicts better adherence and drinking outcomes. American Journal of Geriatric Psychiatry, 10, 740-747.
Pagano, M.E., White, W.L., Kelly, J.F., Stout, R.L. & Tonigan, J.S. (2013) The 10-year course of alcoholics anonymous participation and long-term outcomes: a follow-up study of outpatient subjects in Project MATCH. Substance Abuse, 34, 51-59.
Paris, J. (2011) Dimensional diagnosis and DSM-5. Journal of Clinical Psychiatry, 72, 1340.
Perneczky, R., Wagenpfeil, S., Komossa, K., Grimmer, T., Diehl, J. & Kurz, A. (2006) Mapping scores onto stages: mini-mental state examination and clinical dementia rating. American Journal of Geriatric Psychiatry, 14, 139-144.
Peterson, A.M. (2007) Improving adherence in patients with alcohol dependence: a new role for pharmacists. American Journal of Health System Pharmacy, 64, S23-S29.
Reinert, D.F. & Allen, J.P. (2007) The alcohol use disorders identification test: an update of research findings. Alcoholism, Clinical and Experimental Research, 31, 185-199.
Rohn, M.C., Lee, M.R., Kleuter, S.B., Schwandt, M.L., Falk, D.E. & Leggio, L. (2017) Differences between treatment-seeking and nontreatment-seeking alcohol-dependent research participants: an exploratory analysis. Alcoholism, Clinical and Experimental Research, 41, 414-420.
Rubinsky, A.D., Dawson, D.A., Williams, E.C., Kivlahan, D.R. & Bradley, K.A. (2013) AUDIT-C scores as a scaled marker of mean daily drinking, alcohol use disorder severity, and probability of alcohol dependence in a U.S. general population sample of drinkers. Alcoholism, Clinical and Experimental Research, 37, 1380-1390.
Saxon, A.J., Kivlahan, D.R., Doyle, S. & Donovan, D.M. (2007) Further validation of the alcohol dependence scale as an index of severity. Journal of Studies on Alcohol and Drugs, 68, 149-156.
Schmidt, P., Helten, C. & Soyka, M. (2011) Predictive value of obsessive-compulsive drinking scale (OCDS) for outcome in alcohol-dependent inpatients: results of a 24-month follow-up study. Substance Abuse Treatment, Prevention, and Policy, 6, 14.
Sheehan, D.V., Lecrubier, Y., Sheehan, K.H., Amorim, P., Janavs, J., Weiller, E. et al. (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry, 59(Suppl. 20), 22-33; quiz 34-57.
Skinner, H.A. & Allen, B.A. (1982) Alcohol dependence syndrome: measurement and validation. Journal of Abnormal Psychology, 91, 199-209.
Sliedrecht, W., De Waart, R., Witkiewitz, K. & Roozen, H.G. (2019) Alcohol use disorder relapse factors: a systematic review. Psychiatry Research, 278, 97-115.
Staines, G., Magura, S., Rosenblum, A., Fong, C., Kosanke, N., Foote, J. et al. (2003) Predictors of drinking outcomes among alcoholics. American Journal of Drug and Alcohol Abuse, 29, 203-218.
Tuithof, M., Ten Have, M., Van Den Brink, W., Vollebergh, W. & De Graaf, R. (2014) Alcohol consumption and symptoms as predictors for relapse of DSM-5 alcohol use disorder. Drug and Alcohol Dependence, 140, 85-91.
WHO. (2018) Global status report on alcohol and health 2018. Geneva, Switzerland: World Health Organization.
Yoshimura, A., Komoto, Y. & Higuchi, S. (2016) Exploration of core symptoms for the diagnosis of alcohol dependence in the ICD-10. Alcoholism, Clinical and Experimental Research, 40, 2409-2417.
Aguiar, P., Neto, D., Lambaz, R., Chick, J. & Ferrinho, P. (2012) Prognostic factors during outpatient treatment for alcohol dependence: cohort study with 6 months of treatment follow-up. Alcohol and Alcoholism, 47, 702-710.
American Psychiatric Association. (2013) Diagnostic and statistical manual of mental disorders, 5th edition. DSM-5. Washington, D.C.: American Psychiatric Publishing, Inc.
Andresen-Streichert, H., Muller, A., Glahn, A., Skopp, G. & Sterneck, M. (2018) Alcohol biomarkers in clinical and forensic contexts. Deutsches Ärzteblatt International, 115, 309-315.
Babor, T.F., Steinberg, K., Anton, R. & Del Boca, F. (2000) Talk is cheap: measuring drinking outcomes in clinical trials. Journal of Studies on Alcohol, 61, 55-63.
Boschloo, L., Vogelzangs, N., Van Den Brink, W., Smit, J.H., Beekman, A.T. & Penninx, B.W. (2012a) Predictors of the 2-year recurrence and persistence of alcohol dependence. Addiction, 107, 1639-1640.
Boschloo, L., Vogelzangs, N., Van Den Brink, W., Smit, J.H., Veltman, D.J., Beekman, A.T. et al. (2012b) Alcohol use disorders and the course of depressive and anxiety disorders. British Journal of Psychiatry, 200, 476-484.
Bottlender, M. & Soyka, M. (2005) Efficacy of an intensive outpatient rehabilitation program in alcoholism: predictors of outcome 6 months after treatment. European Addiction Research, 11, 132-137.
Chantarujikapong, S.I., Smith, E.M. & Fox, L.W. (1997) Comparison of the Alcohol Dependence Scale and diagnostic interview schedule in homeless women. Alcoholism, Clinical and Experimental Research, 21, 586-595.
Chiappetta, V., Garcia-Rodriguez, O., Jin, C.J., Secades-Villa, R. & Blanco, C. (2014) Predictors of quit attempts and successful quit attempts among individuals with alcohol use disorders in a nationally representative sample. Drug and Alcohol Dependence, 141, 138-144.
Connolly, J.M., Kavanagh, D.J., Baker, A.L., Kay-Lambkin, F.J., Lewin, T.J., Davis, P.J. et al. (2013) Craving as a predictor of treatment outcomes in heavy drinkers with comorbid depressed mood. Addictive Behaviors, 38, 1585-1592.
Dawson, D.A., Goldstein, R.B. & Grant, B.F. (2007) Rates and correlates of relapse among individuals in remission from DSM-IV alcohol dependence: a 3-year follow-up. Alcoholism, Clinical and Experimental Research, 31, 2036-2045.
Dawson, D.A., Goldstein, R.B., Ruan, W.J. & Grant, B.F. (2012) Correlates of recovery from alcohol dependence: a prospective study over a 3-year follow-up interval. Alcoholism, Clinical and Experimental Research, 36, 1268-1277.
Dawson, D.A., Grant, B.F., Stinson, F.S., Chou, P.S., Huang, B. & Ruan, W.J. (2005) Recovery from DSM-IV alcohol dependence: United States, 2001-2002. Addiction, 100, 281-292.
Hasin, D.S., Liu, X., Alderson, D. & Grant, B.F. (2006) DSM-IV alcohol dependence: a categorical or dimensional phenotype? Psychological Medicine, 36, 1695-1705.
Haug, S. & Schaub, M.P. (2016) Treatment outcome, treatment retention, and their predictors among clients of five outpatient alcohol treatment centres in Switzerland. BMC Public Health, 16, 581.
Langenbucher, J., Sulesund, D., Chung, T. & Morgenstern, J. (1996) Illness severity and self-efficacy as course predictors of DSM-IV alcohol dependence in a multisite clinical sample. Addictive Behaviors, 21, 543-553.
Mann, K., Schafer, D.R., Langle, G., Ackermann, K. & Croissant, B. (2005) The long-term course of alcoholism, 5, 10 and 16 years after treatment. Addiction, 100, 797-805.
Mclellan, A.T., Luborsky, L., Woody, G.E., Obrien, C.P. & Druley, K.A. (1983) Predicting response to alcohol and drug abuse treatments. Role of psychiatric severity. Archives of General Psychiatry, 40, 620-625.
Molander, R.C., Yonker, J.A. & Krahn, D.D. (2010) Age-related changes in drinking patterns from mid- to older age: results from the Wisconsin longitudinal study. Alcoholism, Clinical and Experimental Research, 34, 1182-1192.
Moos, R.H. & Moos, B.S. (2006) Rates and predictors of relapse after natural and treated remission from alcohol use disorders. Addiction, 101, 212-222.
Osaki, Y., Kinjo, A., Higuchi, S., Matsumoto, H., Yuzuriha, T., Horie, Y. et al. (2016) Prevalence and trends in alcohol dependence and alcohol use disorders in Japanese adults; results from periodical nationwide surveys. Alcohol and Alcoholism, 51, 465-473.
Oslin, D.W., Pettinati, H. & Volpicelli, J.R. (2002) Alcoholism treatment adherence: older age predicts better adherence and drinking outcomes. American Journal of Geriatric Psychiatry, 10, 740-747.
Pagano, M.E., White, W.L., Kelly, J.F., Stout, R.L. & Tonigan, J.S. (2013) The 10-year course of alcoholics anonymous participation and long-term outcomes: a follow-up study of outpatient subjects in Project MATCH. Substance Abuse, 34, 51-59.
Paris, J. (2011) Dimensional diagnosis and DSM-5. Journal of Clinical Psychiatry, 72, 1340.
Perneczky, R., Wagenpfeil, S., Komossa, K., Grimmer, T., Diehl, J. & Kurz, A. (2006) Mapping scores onto stages: mini-mental state examination and clinical dementia rating. American Journal of Geriatric Psychiatry, 14, 139-144.
Peterson, A.M. (2007) Improving adherence in patients with alcohol dependence: a new role for pharmacists. American Journal of Health System Pharmacy, 64, S23-S29.
Reinert, D.F. & Allen, J.P. (2007) The alcohol use disorders identification test: an update of research findings. Alcoholism, Clinical and Experimental Research, 31, 185-199.
Rohn, M.C., Lee, M.R., Kleuter, S.B., Schwandt, M.L., Falk, D.E. & Leggio, L. (2017) Differences between treatment-seeking and nontreatment-seeking alcohol-dependent research participants: an exploratory analysis. Alcoholism, Clinical and Experimental Research, 41, 414-420.
Rubinsky, A.D., Dawson, D.A., Williams, E.C., Kivlahan, D.R. & Bradley, K.A. (2013) AUDIT-C scores as a scaled marker of mean daily drinking, alcohol use disorder severity, and probability of alcohol dependence in a U.S. general population sample of drinkers. Alcoholism, Clinical and Experimental Research, 37, 1380-1390.
Saxon, A.J., Kivlahan, D.R., Doyle, S. & Donovan, D.M. (2007) Further validation of the alcohol dependence scale as an index of severity. Journal of Studies on Alcohol and Drugs, 68, 149-156.
Schmidt, P., Helten, C. & Soyka, M. (2011) Predictive value of obsessive-compulsive drinking scale (OCDS) for outcome in alcohol-dependent inpatients: results of a 24-month follow-up study. Substance Abuse Treatment, Prevention, and Policy, 6, 14.
Sheehan, D.V., Lecrubier, Y., Sheehan, K.H., Amorim, P., Janavs, J., Weiller, E. et al. (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry, 59(Suppl. 20), 22-33; quiz 34-57.
Skinner, H.A. & Allen, B.A. (1982) Alcohol dependence syndrome: measurement and validation. Journal of Abnormal Psychology, 91, 199-209.
Sliedrecht, W., De Waart, R., Witkiewitz, K. & Roozen, H.G. (2019) Alcohol use disorder relapse factors: a systematic review. Psychiatry Research, 278, 97-115.
Staines, G., Magura, S., Rosenblum, A., Fong, C., Kosanke, N., Foote, J. et al. (2003) Predictors of drinking outcomes among alcoholics. American Journal of Drug and Alcohol Abuse, 29, 203-218.
Tuithof, M., Ten Have, M., Van Den Brink, W., Vollebergh, W. & De Graaf, R. (2014) Alcohol consumption and symptoms as predictors for relapse of DSM-5 alcohol use disorder. Drug and Alcohol Dependence, 140, 85-91.
WHO. (2018) Global status report on alcohol and health 2018. Geneva, Switzerland: World Health Organization.
Yoshimura, A., Komoto, Y. & Higuchi, S. (2016) Exploration of core symptoms for the diagnosis of alcohol dependence in the ICD-10. Alcoholism, Clinical and Experimental Research, 40, 2409-2417.
Contributed Indexing:
Keywords: abstinence; alcohol dependence; clinical course; controlled drinking; severity
Entry Date(s):
Date Created: 20210929 Date Completed: 20220323 Latest Revision: 20220323
Update Code:
20250114
DOI:
10.1111/acer.14707
PMID:
34585408
Database:
MEDLINE
Weitere Informationen
Background: While accumulating evidence suggests a relation between the severity of alcohol dependence and the risk of its recurrence, the impact of dependence severity on the course of the disorder has not been carefully evaluated. The present study examined the impact of several severity indices of alcohol dependence on the drinking course after inpatient treatment.
Methods: This prospective study was conducted over a 12-month period following alcohol treatment at a specialized hospital. A total of 712 consecutively admitted alcohol-dependent patients were targeted for enrollment at the time of their hospitalization, with 637 patients registered and followed. The characteristics and severity of the subjects were assessed using multiple methods at admission, with their course after discharge followed continuously using mailed questionnaires that queried them regarding their drinking behavior.
Results: Greater severity of dependence, assessed using the number of ICD-10 diagnostic criteria met, was associated with a lower rate of abstinence during the study period (p = 0.035). The rate of abstinence also decreased significantly as the baseline blood gamma-glutamyl transferase value and Alcohol Dependence Scale (ADS) score increased (p = 0.031 and p = 0.0002, respectively). In multivariate Cox proportional hazards analyses, the group with the most severe ADS scores had a significantly greater risk of relapse to drinking than the group with the least severe scores (HR = 2.67, p = 0.001). Dependence severity also associated with the drinking pattern; participants in both the controlled drinking group and the abstinence group had lower ADS scores at admission and a later age at first drinking (p = 0.001 and p < 0.001, respectively) than those with poorer drinking outcomes.
Conclusions: The present study showed that more severe alcohol dependence predicts a poorer course after alcohol treatment, as reflected by findings on multiple measures. These results suggest that assessing the dependence severity at the outset of treatment could be useful both in predicting treatment outcome and targeting interventions to alcohol-dependent individuals who need additional support in their recovery.
(© 2021 by the Research Society on Alcoholism.)