• PyLabRobot: An Open-Source, Ha...

Treffer: PyLabRobot: An Open-Source, Hardware Agnostic Interface for Liquid-Handling Robots and Accessories.

Title:
PyLabRobot: An Open-Source, Hardware Agnostic Interface for Liquid-Handling Robots and Accessories.
Authors:
Wierenga RP; Leiden University, Leiden, the Netherlands.; Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA., Golas S; Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA., Ho W; Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Coley C; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Esvelt KM; Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.
Source:
BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 15. Date of Electronic Publication: 2023 Jul 15.
Publication Type:
Preprint; Journal Article
Language:
English
Journal Info:
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
References:
SLAS Discov. 2023 Jun;28(4):193-201. (PMID: 37121274)
Nature. 2023 Dec;624(7992):570-578. (PMID: 38123806)
Nature. 2020 Sep;585(7825):357-362. (PMID: 32939066)
J Lab Autom. 2016 Dec;21(6):765-778. (PMID: 26856613)
Adv Mater. 2022 Jul;34(30):e2201809. (PMID: 35593444)
J Am Chem Soc. 2021 Dec 1;143(47):19945-19955. (PMID: 34793161)
Nat Methods. 2022 Jan;19(1):55-64. (PMID: 34969982)
J Vis Exp. 2017 Dec 1;(130):. (PMID: 29286379)
Mol Syst Biol. 2021 Mar;17(3):e9942. (PMID: 33764680)
SLAS Technol. 2019 Jun;24(3):282-290. (PMID: 30768372)
Nat Biomed Eng. 2020 Sep;4(9):863-874. (PMID: 32514094)
Nat Protoc. 2024 Feb;19(2):565-594. (PMID: 38087082)
J Lab Autom. 2012 Apr;17(2):86-95. (PMID: 22357556)
Grant Information:
DP2 AI136597 United States AI NIAID NIH HHS; R21 AI158169 United States AI NIAID NIH HHS
Contributed Indexing:
Keywords: Liquid handling robots; laboratory automation; open source; standardization
Entry Date(s):
Date Created: 20230728 Latest Revision: 20240923
Update Code:
20250114
PubMed Central ID:
PMC10369895
DOI:
10.1101/2023.07.10.547733
PMID:
37502883
Database:
MEDLINE

Weitere Informationen

Liquid handling robots are often limited by proprietary programming interfaces that are only compatible with a single type of robot and operating system, restricting method sharing and slowing development. Here we present PyLabRobot, an open-source, cross-platform Python interface capable of programming diverse liquid-handling robots, including Hamilton STARs, Tecan EVOs, and Opentron OT-2s. PyLabRobot provides a universal set of commands and representations for deck layout and labware, enabling the control of diverse accessory devices. The interface is extensible and can work with any robot that manipulates liquids within a Cartesian coordinate system. We validated the system through unit tests and several application demonstrations, including a browser-based simulator, a position calibration tool, and a path-teaching tool for complex movements. PyLabRobot provides a flexible, open, and collaborative programming environment for laboratory automation.

Declaration of Interests The authors declare no competing interests.