• A comparison of functional act...

Treffer: A comparison of functional activation and connectivity of the cerebellum in adults and children during single word processing.

Title:
A comparison of functional activation and connectivity of the cerebellum in adults and children during single word processing.
Authors:
Ashburn SM; Center for the Study of Learning, Department of Pediatrics, Georgetown University Medical Center, Washington, DC, United States., Lynn Flowers D; Center for the Study of Learning, Department of Pediatrics, Georgetown University Medical Center, Washington, DC, United States., Eden GF; Center for the Study of Learning, Department of Pediatrics, Georgetown University Medical Center, Washington, DC, United States. Electronic address: edeng@georgetown.edu.
Source:
Brain and language [Brain Lang] 2023 Nov; Vol. 246, pp. 105346. Date of Electronic Publication: 2023 Oct 29.
Publication Type:
Journal Article; Research Support, N.I.H., Extramural
Language:
English
Journal Info:
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7506220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2155 (Electronic) Linking ISSN: 0093934X NLM ISO Abbreviation: Brain Lang Subsets: MEDLINE
Imprint Name(s):
Publication: <2000- > : Amsterdam : Elsevier
Original Publication: New York, Academic Press.
MeSH Terms:
Brain Mapping* , Word Processing*, Humans ; Adult ; Child ; Cerebellum ; Reading ; Cerebral Cortex ; Magnetic Resonance Imaging/methods
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Grant Information:
P50 HD040095 United States HD NICHD NIH HHS; P30 HD040677 United States HD NICHD NIH HHS; TL1 TR001431 United States TR NCATS NIH HHS; R01 HD081078 United States HD NICHD NIH HHS; T32 NS041218 United States NS NINDS NIH HHS
Contributed Indexing:
Keywords: Adults; Cerebellum; Children; Functional Activation; Functional Connectivity; Reading
Entry Date(s):
Date Created: 20231123 Date Completed: 20231124 Latest Revision: 20241102
Update Code:
20250114
PubMed Central ID:
PMC10722870
DOI:
10.1016/j.bandl.2023.105346
PMID:
37994829
Database:
MEDLINE

Weitere Informationen

Meta-analyses on reading show cerebellar activation in adults, but not children, suggesting a possible age-dependent role of the cerebellum in reading. However, the few studies that compare adults and children during reading report mixed cerebellar activation results. Here, we studied (i) cerebellar activation during implicit word processing in adults and children and (ii) functional connectivity (FC) between the cerebellum and left cortical regions involved in reading. First, both groups activated bilateral cerebellum for word processing when compared to fixation, but not when compared to the active control. There were no differences between adults and children. Second, we found intrinsic FC between several cerebellar seed regions and cortical target regions in adults and children, as well as between-group differences. However, task-modulated FC specific to word processing revealed no within- nor between-group results. Together this study does not provide support for a role of the cerebellum in word processing at either age.
(Copyright © 2023 Elsevier Inc. All rights reserved.)

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.