Treffer: An evolved interpretation of Austin Bradford Hill's causal viewpoints and their influence on epidemiologic methods.
Original Publication: Baltimore, School of Hygiene and Public Health of Johns Hopkins Univ.
Proc R Soc Med. 1965 May;58:295-300. (PMID: 14283879)
Epidemiology. 2011 May;22(3):368-77. (PMID: 21399502)
Nutrients. 2022 Sep 15;14(18):. (PMID: 36145186)
Epidemiology. 2015 Sep;26(5):710-3. (PMID: 26196685)
Am J Epidemiol. 2002 Jan 15;155(2):176-84. (PMID: 11790682)
J Clin Epidemiol. 2018 Aug;100:22-31. (PMID: 29654822)
Ann Intern Med. 2011 May 17;154(10):680-3. (PMID: 21576536)
Int J Epidemiol. 1999 Feb;28(1):1-9. (PMID: 10195657)
Stat Med. 2000 Jul 15;19(13):1707-28. (PMID: 10861773)
Epidemiology. 2019 May;30(3):334-341. (PMID: 30789432)
Am J Epidemiol. 1986 Nov;124(5):711-8. (PMID: 3532766)
J Clin Epidemiol. 2011 Apr;64(4):401-6. (PMID: 21208779)
Int J Epidemiol. 2001 Jun;30(3):427-32; discussion 433-4. (PMID: 11416056)
Int J Epidemiol. 1988 Dec;17(4):955-9. (PMID: 3225112)
Emerg Themes Epidemiol. 2015 Sep 30;12:14. (PMID: 26425136)
Epidemiology. 2001 Mar;12(2):246-55. (PMID: 11246588)
Epidemiology. 2009 Nov;20(6):863-71. (PMID: 19806059)
Cancer Epidemiol Biomarkers Prev. 1996 Apr;5(4):303-11. (PMID: 8722223)
Scand J Work Environ Health. 1988 Apr;14(2):125-9. (PMID: 3387960)
J Epidemiol Community Health. 2015 Jan;69(1):92-4. (PMID: 25124189)
Epidemiology. 2022 Sep 1;33(5):699-706. (PMID: 35700187)
Am J Epidemiol. 2010 Jul 1;172(1):107-15. (PMID: 20547574)
Epidemiology. 2010 Jan;21(1):3-9. (PMID: 20010205)
Epidemiology. 1999 Jan;10(1):37-48. (PMID: 9888278)
Epidemiology. 2019 May;30(3):311-316. (PMID: 30789434)
J Natl Cancer Inst. 1959 Jan;22(1):173-203. (PMID: 13621204)
Epidemiology. 2004 Sep;15(5):615-25. (PMID: 15308962)
Int J Epidemiol. 2016 Dec 1;45(6):1866-1886. (PMID: 28108528)
Epidemiology. 1992 May;3(3):210-5. (PMID: 1591319)
J Epidemiol Community Health. 2011 May;65(5):392-5. (PMID: 20947872)
Int J Epidemiol. 2002 Apr;31(2):422-9. (PMID: 11980807)
Epidemiology. 2010 May;21(3):383-8. (PMID: 20335814)
BMJ. 1998 Jan 10;316(7125):140-4. (PMID: 9462324)
Biometrics. 2019 Jun;75(2):685-694. (PMID: 30488513)
JAMA. 2019 Feb 12;321(6):602-603. (PMID: 30676631)
Epidemiology. 2015 Sep;26(5):714-8. (PMID: 26196684)
Epidemiol Perspect Innov. 2004 Oct 04;1(1):3. (PMID: 15507128)
Am J Epidemiol. 2021 Jan 4;190(1):142-149. (PMID: 32596726)
Int J Epidemiol. 2009 Oct;38(5):1199-201. (PMID: 19773411)
Int J Epidemiol. 2000 Aug;29(4):722-9. (PMID: 10922351)
Epidemiology. 2017 Jul;28(4):553-561. (PMID: 28346267)
Environ Health Perspect. 2015 Jun;123(6):507-14. (PMID: 25712798)
Int J Epidemiol. 2015 Aug;44(4):1452-9. (PMID: 25921223)
Epidemiology. 2016 Jan;27(1):91-7. (PMID: 26484424)
Emerg Themes Epidemiol. 2005 Nov 03;2:11. (PMID: 16269083)
N Engl J Med. 1958 Dec 18;259(25):1210-4. (PMID: 13622912)
J Health Soc Behav. 1995;Spec No:80-94. (PMID: 7560851)
Eur J Epidemiol. 2019 Nov;34(11):1025-1053. (PMID: 31624969)
Am J Public Health. 2017 Jul;107(7):1087-1091. (PMID: 28590865)
Ann Intern Med. 2017 Aug 15;167(4):268-274. (PMID: 28693043)
Am J Epidemiol. 1976 Dec;104(6):587-92. (PMID: 998606)
Biometrics. 2018 Sep;74(3):785-794. (PMID: 29141096)
Int J Epidemiol. 2022 May 9;51(2):355-363. (PMID: 35229872)
Epidemiology. 2007 Jul;18(4):518-9. (PMID: 17568225)
Am J Epidemiol. 2014 Apr 1;179(7):797-806. (PMID: 24573538)
Weitere Informationen
In 1965, Sir Austin Bradford Hill articulated nine viewpoints for evaluating whether a body of evidence about the relationship between an exposure and outcome should be interpreted causally. In this commentary, we highlight a selection of the ways in which these viewpoints have had an impact on the field of epidemiology in terms of methods development, study design, and interpretation of results. Additionally, we opine on how the viewpoints relate to our understanding of basic epidemiologic concepts-for example, our choice of absolute or relative measures of effect, our evolving understanding of the role of context in the generalizability of study results, and modern epistemologies for causal inference (ie, the potential outcomes framework and graphical causal models). Hill cautioned his audience that evidence should be weighed according to the policy choice it would inform and the context in which that policy would be implemented. We root our remarks in considerations of the public health impact of our conclusions about the causal nature of an observed relationship.
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