Treffer: miRNASNP-v4: a comprehensive database for miRNA-related SNPs across 17 species.

Title:
miRNASNP-v4: a comprehensive database for miRNA-related SNPs across 17 species.
Authors:
Cao W; Hubei Hongshan Laboratory, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., He J; Hubei Hongshan Laboratory, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China., Feng J; Hubei Hongshan Laboratory, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China., Wu X; Hubei Hongshan Laboratory, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China., Wu T; Hubei Hongshan Laboratory, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China., Wang D; Hubei Hongshan Laboratory, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China., Min C; Hubei Hongshan Laboratory, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China., Niu X; Hubei Hongshan Laboratory, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China., Gao Z; Hubei Hongshan Laboratory, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.; College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China., Guo AY; Department of thoracic surgery, West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu 610041, China., Gong J; Hubei Hongshan Laboratory, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.; College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China.
Source:
Nucleic acids research [Nucleic Acids Res] 2025 Jan 06; Vol. 53 (D1), pp. D1066-D1074.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Imprint Name(s):
Publication: 1992- : Oxford : Oxford University Press
Original Publication: London, Information Retrieval ltd.
MeSH Terms:
MicroRNAs*/genetics , MicroRNAs*/metabolism , Polymorphism, Single Nucleotide* , 3' Untranslated Regions*/genetics , Databases, Nucleic Acid*, Humans ; Animals ; Binding Sites/genetics ; Software ; Nucleic Acid Conformation ; Databases, Genetic
Grant Information:
2021YFF0703703 National Key R&D Program of China; 32425054 National Natural Science Foundation of China
Substance Nomenclature:
0 (MicroRNAs)
0 (3' Untranslated Regions)
Entry Date(s):
Date Created: 20241016 Date Completed: 20250108 Latest Revision: 20250116
Update Code:
20250117
PubMed Central ID:
PMC11701550
DOI:
10.1093/nar/gkae888
PMID:
39413204
Database:
MEDLINE

Weitere Informationen

Single nucleotide polymorphisms (SNPs) within microRNAs (miRNAs) and their target binding sites can influence miRNA biogenesis and target regulation, thereby participating in a variety of diseases and biological processes. Current miRNA-related SNP databases are often species-limited or based on outdated data. Therefore, we updated our miRNASNP database to version 4 by updating data, expanding the species from Homo sapiens to 17 species, and introducing several new features. In miRNASNP-v4, 82 580 SNPs in miRNAs and 24 836 179 SNPs in 3'UTRs of genes across 17 species were identified and their potential effects on miRNA secondary structure and target binding were characterized. In addition, compared to the last release, miRNASNP-v4 includes the following improvements: (i) gene enrichment analysis for gained or lost miRNA target genes; (ii) identification of miRNA-related SNPs associated with drug response and immune infiltration in human cancers; (iii) inclusion of experimentally supported immune-related miRNAs and (iv) online prediction tools for 17 animal species. With the extensive data and user-friendly web interface, miRNASNP-v4 will serve as an invaluable resource for functional studies of SNPs and miRNAs in multiple species. The database is freely accessible at http://gong_lab.hzau.edu.cn/miRNASNP/.
(© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.)