Treffer: Antifungal resistance: Emerging mechanisms and implications (Review).
Title:
Antifungal resistance: Emerging mechanisms and implications (Review).
Authors:
Kadariswantiningsih IN; Department of Medical Microbiology, Faculty of Medicine, Airlangga University, Surabaya, East Java 60131, Indonesia., Empitu MA; Department of Pharmacology, Faculty of Medicine, Airlangga University, Surabaya, East Java 60131, Indonesia., Santosa TI; Department of Pharmacology, Faculty of Medicine, Airlangga University, Surabaya, East Java 60131, Indonesia., Alimu Y; Department of Cutaneous Allergy and Host Defense, Immunology Frontier Research Center, Osaka University, Osaka, Honshu 5650871, Japan.
Source:
Molecular medicine reports [Mol Med Rep] 2025 Sep; Vol. 32 (3). Date of Electronic Publication: 2025 Jul 11.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-3004 (Electronic) Linking ISSN: 17912997 NLM ISO Abbreviation: Mol Med Rep Subsets: MEDLINE
Imprint Name(s):
Original Publication: Athens, Greece : D. A. Spandidos
MeSH Terms:
References:
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BMC Genomics. 2010 Mar 16;11:177. (PMID: 20233411)
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Front Cell Infect Microbiol. 2013 Nov 11;3:74. (PMID: 24273749)
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Antimicrob Agents Chemother. 2006 Nov;50(11):3839-46. (PMID: 16923951)
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Ann Hematol. 2008 Nov;87(11):915-22. (PMID: 18641986)
Nat Rev Microbiol. 2020 Jun;18(6):319-331. (PMID: 32047294)
Sci Transl Med. 2012 Dec 19;4(165):165rv13. (PMID: 23253612)
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Sci Rep. 2015 Feb 24;5:8567. (PMID: 25708804)
mSphere. 2019 Aug 7;4(4):. (PMID: 31391280)
Chem Rev. 2021 Mar 24;121(6):3390-3411. (PMID: 32441527)
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Curr Opin Microbiol. 2018 Oct;45:70-76. (PMID: 29547801)
J Fungi (Basel). 2021 Sep 06;7(9):. (PMID: 34575770)
PLoS Pathog. 2019 Jul 29;15(7):e1007945. (PMID: 31356623)
PLoS One. 2012;7(1):e30349. (PMID: 22276181)
Front Immunol. 2022 Aug 22;13:883638. (PMID: 36072605)
Nat Commun. 2018 Jun 25;9(1):2470. (PMID: 29941885)
Nat Microbiol. 2022 Aug;7(8):1239-1251. (PMID: 35918426)
Biomedicines. 2023 Mar 14;11(3):. (PMID: 36979876)
Antimicrob Agents Chemother. 1997 Jul;41(7):1482-7. (PMID: 9210670)
J Fungi (Basel). 2021 Aug 14;7(8):. (PMID: 34436200)
Antimicrob Agents Chemother. 2020 Aug 20;64(9):. (PMID: 32571823)
Microbiol Spectr. 2023 Feb 28;:e0301622. (PMID: 36853047)
J Fungi (Basel). 2020 Aug 18;6(3):. (PMID: 32824785)
Cell. 2012 Jan 20;148(1-2):126-38. (PMID: 22265407)
Cold Spring Harb Perspect Med. 2014 May 01;4(5):. (PMID: 24789878)
Drug Deliv. 2018 Nov;25(1):78-90. (PMID: 29239242)
Clin Infect Dis. 2025 Apr 09;:. (PMID: 40203286)
Fungal Genet Biol. 2019 Nov;132:103253. (PMID: 31325489)
FEMS Yeast Res. 2013 Jun;13(4):386-93. (PMID: 23480635)
Mol Microbiol. 2012 Nov;86(3):539-56. (PMID: 22924823)
J Fungi (Basel). 2023 Jan 29;9(2):. (PMID: 36836298)
Virulence. 2015;6(6):618-30. (PMID: 26103530)
Int J Pharm. 2015 Nov 10;495(1):599-607. (PMID: 26383840)
Nat Commun. 2024 Oct 24;15(1):9194. (PMID: 39448635)
Science. 2008 Oct 31;322(5902):703-9. (PMID: 18974345)
Microbiol Spectr. 2024 Mar 5;12(3):e0330423. (PMID: 38315027)
Antimicrob Agents Chemother. 2012 Feb;56(2):935-41. (PMID: 22123686)
J Biomed Mater Res A. 2020 Nov 1;108(11):2263-2276. (PMID: 32363762)
EMBO J. 2002 Feb 15;21(4):546-59. (PMID: 11847103)
Front Microbiol. 2018 Dec 03;9:2946. (PMID: 30559734)
Front Cell Infect Microbiol. 2024 Jun 20;14:1397724. (PMID: 38966251)
Antimicrob Agents Chemother. 2003 Mar;47(3):1120-4. (PMID: 12604551)
Clin Microbiol Rev. 2009 Apr;22(2):291-321, Table of Contents. (PMID: 19366916)
J Fungi (Basel). 2022 Aug 19;8(8):. (PMID: 36012862)
EXCLI J. 2021 Mar 08;20:562-584. (PMID: 33883983)
Antimicrob Agents Chemother. 2018 Feb 23;62(3):. (PMID: 29311085)
Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12809-12814. (PMID: 27791100)
PLoS Pathog. 2018 Oct 18;14(10):e1007301. (PMID: 30335865)
PLoS Genet. 2009 Oct;5(10):e1000705. (PMID: 19876375)
Antimicrob Agents Chemother. 2015 Dec 07;60(2):1079-84. (PMID: 26643334)
mBio. 2011 Jul 26;2(4):. (PMID: 21791579)
Cold Spring Harb Perspect Med. 2014 Nov 10;5(7):a019752. (PMID: 25384768)
Antimicrob Agents Chemother. 2001 Dec;45(12):3416-21. (PMID: 11709317)
Microorganisms. 2018 Dec 04;6(4):. (PMID: 30518069)
Front Microbiol. 2021 Jan 22;11:616922. (PMID: 33552027)
Antimicrob Agents Chemother. 2023 Feb 16;67(2):e0068622. (PMID: 36688672)
Antimicrob Agents Chemother. 2014 Jul;58(7):3626-35. (PMID: 24733467)
Cell Host Microbe. 2024 Feb 14;32(2):276-289.e7. (PMID: 38215741)
Microbiol Spectr. 2017 Jul;5(4):. (PMID: 28721856)
mBio. 2017 May 30;8(3):. (PMID: 28559486)
J Med Chem. 2000 Jun 29;43(13):2493-505. (PMID: 10891108)
Nat Commun. 2025 Apr 06;16(1):3287. (PMID: 40189588)
mSphere. 2022 Jun 29;7(3):e0008722. (PMID: 35638358)
Drug Resist Updat. 2015 Nov;23:12-19. (PMID: 26690338)
Microorganisms. 2022 Sep 21;10(10):. (PMID: 36296159)
Antibiotics (Basel). 2022 May 12;11(5):. (PMID: 35625289)
BMC Microbiol. 2020 Feb 7;20(1):28. (PMID: 32028887)
J Fungi (Basel). 2017 Feb 21;3(1):. (PMID: 29371527)
Microbiol Spectr. 2022 Jun 29;10(3):e0096322. (PMID: 35658596)
Mycoses. 2014 Jun;57(6):342-50. (PMID: 24373120)
Lancet Infect Dis. 2017 Aug;17(8):873-881. (PMID: 28483415)
Antimicrob Agents Chemother. 2021 Jan 20;65(2):. (PMID: 33229427)
J Fungi (Basel). 2020 Dec 22;7(1):. (PMID: 33374996)
J Antimicrob Chemother. 2015 Jul;70(7):1993-2003. (PMID: 25825380)
Mycoses. 2021 Jan;64(1):78-85. (PMID: 33000505)
Science. 2018 May 18;360(6390):739-742. (PMID: 29773744)
Science. 2007 Aug 17;317(5840):916-24. (PMID: 17702937)
Curr Pharm Des. 2013;19(20):3713-37. (PMID: 23278536)
G3 (Bethesda). 2017 Aug 7;7(8):2413-2426. (PMID: 28663342)
Emerg Infect Dis. 2020 Jul;26(7):1447-1455. (PMID: 32568033)
Front Microbiol. 2016 Dec 15;7:1995. (PMID: 28018323)
Infect Drug Resist. 2017 Aug 29;10:249-259. (PMID: 28919789)
Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6135-E6144. (PMID: 27681634)
Nat Commun. 2016 Mar 29;7:11128. (PMID: 27020939)
Antimicrob Agents Chemother. 2007 Nov;51(11):4174-6. (PMID: 17724146)
J Mol Evol. 2023 Jun;91(3):369-377. (PMID: 36752826)
mBio. 2023 Dec 19;14(6):e0268823. (PMID: 38014938)
Cell Mol Life Sci. 2014 Jul;71(14):2651-66. (PMID: 24526056)
Fungal Genet Biol. 2010 Feb;47(2):127-42. (PMID: 19857594)
Genes (Basel). 2019 Oct 10;10(10):. (PMID: 31658789)
Microbiology (Reading). 2002 Apr;148(Pt 4):1061-1072. (PMID: 11932451)
BMC Genomics. 2011 Oct 27;12:526. (PMID: 22032296)
PLoS Pathog. 2010 Apr 01;6(4):e1000848. (PMID: 20368972)
Clin Infect Dis. 2002 Nov 1;35(9):1073-80. (PMID: 12384841)
Antimicrob Agents Chemother. 2005 Jul;49(7):2851-6. (PMID: 15980360)
Clin Microbiol Rev. 1998 Apr;11(2):382-402. (PMID: 9564569)
J Photochem Photobiol B. 2021 Mar;216:112131. (PMID: 33517071)
Elife. 2015 Feb 03;4:e00662. (PMID: 25646566)
Antimicrob Agents Chemother. 2022 May 17;66(5):e0225021. (PMID: 35471041)
Annu Rev Microbiol. 2017 Sep 8;71:413-439. (PMID: 28715960)
N Engl J Med. 2022 Mar 24;386(12):1109-1120. (PMID: 35320642)
Drugs. 2016 Mar;76(4):485-500. (PMID: 26818726)
mBio. 2015 Mar 31;6(2):. (PMID: 25827423)
NPJ Antimicrob Resist. 2023;1(1):5. (PMID: 38686214)
J Fungi (Basel). 2017 Oct 18;3(4):. (PMID: 29371573)
Contributed Indexing:
Keywords: antifungal; epigenetic; infectious disease; resistance
Substance Nomenclature:
0 (Antifungal Agents)
Entry Date(s):
Date Created: 20250711 Date Completed: 20250918 Latest Revision: 20250918
Update Code:
20250918
PubMed Central ID:
PMC12272148
DOI:
10.3892/mmr.2025.13612
PMID:
40641105
Database:
MEDLINE
Weitere Informationen
Antifungal resistance is a growing concern in clinical medicine, driven by the increasing incidence of fungal infections and the limited arsenal of effective antifungal drugs. This resistance is achieved by intrinsic mechanisms, such as ineffective drug‑target binding, high efflux pump activity and unique cell wall and membrane composition, as well as acquired mechanisms, including genetic mutations, gene duplication, transposon insertions, aneuploidies and loss of heterozygosity. Antifungal tolerance, characterized by subpopulations of fungal cells that persist and proliferate even at high drug concentrations, complicates treatment. The present review aimed to examine the genetic, physiological and epigenetic factors that contribute to antifungal resistance and tolerance. Understanding these mechanisms may enable the development of novel antifungal therapies and effective diagnostic strategies to combat the increasing threat of resistant fungal infection. Advanced diagnostic tools and combination therapies are key for managing resistant infections and ongoing research into these mechanisms may enhance the ability to mitigate antifungal resistance.