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Treffer: Aerobic walking exercise training boosts thalamic connectivity in MS patients with cognitive processing speed impairment.

Title:
Aerobic walking exercise training boosts thalamic connectivity in MS patients with cognitive processing speed impairment.
Authors:
Sandroff BM; Center for Neuropsychology and Neuroscience Research, Kessler Foundation, West Orange, NJ, United States; Department of Physical Medicine and Rehabilitation, Rutgers NJ Medical School, Newark, NJ, United States. Electronic address: bsandroff@kesslerfoundation.org., Motl RW; Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, United States., Wylie GR; Center for Neuropsychology and Neuroscience Research, Kessler Foundation, West Orange, NJ, United States; Department of Physical Medicine and Rehabilitation, Rutgers NJ Medical School, Newark, NJ, United States., Wells GE; Center for Neuropsychology and Neuroscience Research, Kessler Foundation, West Orange, NJ, United States., Wender CLA; Center for Neuropsychology and Neuroscience Research, Kessler Foundation, West Orange, NJ, United States; Department of Physical Medicine and Rehabilitation, Rutgers NJ Medical School, Newark, NJ, United States., Picone MA; Holy Name Multiple Sclerosis Center, Teaneck, NJ, United States., Pandey K; Hackensack Meridian Multiple Sclerosis Center, Hackensack, NJ, United States., DeLuca J; Center for Neuropsychology and Neuroscience Research, Kessler Foundation, West Orange, NJ, United States; Department of Physical Medicine and Rehabilitation, Rutgers NJ Medical School, Newark, NJ, United States., Cutter GR; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, United States.
Source:
Brain and cognition [Brain Cogn] 2025 Oct; Vol. 189, pp. 106349. Date of Electronic Publication: 2025 Aug 09.
Publication Type:
Journal Article; Randomized Controlled Trial
Language:
English
Journal Info:
Publisher: Academic Press Country of Publication: United States NLM ID: 8218014 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2147 (Electronic) Linking ISSN: 02782626 NLM ISO Abbreviation: Brain Cogn Subsets: MEDLINE
Imprint Name(s):
Original Publication: New York : Academic Press, [c1982-
MeSH Terms:
Thalamus*/physiopathology , Thalamus*/diagnostic imaging , Walking*/physiology , Multiple Sclerosis*/physiopathology , Multiple Sclerosis*/complications , Multiple Sclerosis*/diagnostic imaging , Exercise Therapy*/methods , Exercise*/physiology , Cognitive Dysfunction*/physiopathology , Cognitive Dysfunction*/diagnostic imaging, Humans ; Female ; Male ; Adult ; Middle Aged ; Magnetic Resonance Imaging ; Single-Blind Method ; Cerebral Cortex/physiopathology ; Cerebral Cortex/diagnostic imaging ; Processing Speed
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Grant Information:
R01 HD091155 United States HD NICHD NIH HHS
Contributed Indexing:
Keywords: Brain; Cognition; Exercise; Multiple sclerosis; Neuroimaging
Entry Date(s):
Date Created: 20250810 Date Completed: 20250907 Latest Revision: 20250909
Update Code:
20250909
PubMed Central ID:
PMC12381831
DOI:
10.1016/j.bandc.2025.106349
PMID:
40784215
Database:
MEDLINE

Weitere Informationen

Purpose: The current study involved a single-blind, randomized controlled trial on the effects of aerobic treadmill walking exercise training compared with an active control condition as an approach to modify thalamocortical resting-state functional connectivity (RSFC) as a neurobiological correlate of cognitive processing speed (CPS) impairment in 28 fully-ambulatory persons with multiple sclerosis (MS) who were pre-screened for impaired CPS.
Methods: Participants completed baseline assessments of CPS and underwent resting-state fMRI to measure thalamocortical RSFC. Following baseline, participants were randomly assigned into either 12-weeks of supervised, aerobic treadmill walking exercise training or 12-weeks of stretching and range-of-motion activities (active control condition). After the 12-week study period, participants underwent follow-up assessments of CPS and thalamocortical RSFC using a treatment-blinded assessor.
Results: Aerobic treadmill walking exercise training was associated with significantly increased RSFC between the thalamus and frontal/parietal regions relative to the active control condition. By comparison, the active control condition was associated with significantly increased RSFC between the thalamus and occipital regions relative to the treadmill condition.
Conclusions: The current RCT provides critical information on underlying neurophysiological mechanisms of aerobic treadmill walking exercise training and stretching and range-of-motion activities among fully-ambulatory, but CPS impaired persons with MS. This is important for informing the design of aerobic exercise programs that selectively target thalamocortical RSFC as an approach to improve CPS in persons with MS. Such programs may be ripe for inclusion in a future mechanistic trial focusing on thalamocortical RSFC as a mediator of exercise effects on CPS in MS.
(Copyright © 2025 Elsevier Inc. All rights reserved.)

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.