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Treffer: Pulling back the curtain: the road from statistical estimand to machine-learning-based estimator for epidemiologists (no wizard required).

Title:
Pulling back the curtain: the road from statistical estimand to machine-learning-based estimator for epidemiologists (no wizard required).
Authors:
Renson A; Department of Population Health, New York University Grossman School of Medicine, New York 10016, United States., Montoya L; School of Data Science and Society, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, United States.; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States., Goin DE; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York 10032, United States., Díaz I; Department of Population Health, New York University Grossman School of Medicine, New York 10016, United States., Ross RK; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York 10032, United States.
Source:
American journal of epidemiology [Am J Epidemiol] 2025 Dec 02; Vol. 194 (12), pp. 3566-3571.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Oxford University Press Country of Publication: United States NLM ID: 7910653 Publication Model: Print Cited Medium: Internet ISSN: 1476-6256 (Electronic) Linking ISSN: 00029262 NLM ISO Abbreviation: Am J Epidemiol Subsets: MEDLINE
Imprint Name(s):
Publication: Cary, NC : Oxford University Press
Original Publication: Baltimore, School of Hygiene and Public Health of Johns Hopkins Univ.
Grant Information:
R00MH133985 United States NH NIH HHS; R00ES033274 United States NH NIH HHS; Bezos foundation
Contributed Indexing:
Keywords: causal inference; efficient influence functions; machine learning; semiparametric theory
Entry Date(s):
Date Created: 20250812 Date Completed: 20251202 Latest Revision: 20251204
Update Code:
20251204
PubMed Central ID:
PMC12671979
DOI:
10.1093/aje/kwaf169
PMID:
40796167
Database:
MEDLINE

Weitere Informationen

Epidemiologists increasingly use causal inference methods that rely on machine learning, as these approaches can relax unnecessary model specification assumptions. While deriving and studying asymptotic properties of such estimators is a task usually associated with statisticians, it is useful for epidemiologists to understand the steps involved, as epidemiologists are often at the forefront of defining important new research questions and translating them into new parameters to be estimated. In this paper, our goal was to provide a relatively accessible guide through the process of (1) deriving an estimator based on the so-called efficient influence function (which we define and explain), and (2) showing such an estimator's ability to validly incorporate machine learning, by demonstrating the so-called rate double robustness property. The derivations in this paper rely mainly on algebra and some foundational results from statistical inference, which are explained.
(© The Author(s) 2025. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com.)