• Aminoacyl-tRNA synthetase: A &...

Treffer: Aminoacyl-tRNA synthetase: A 'semiotic enzyme'.

Title:
Aminoacyl-tRNA synthetase: A 'semiotic enzyme'.
Authors:
Prathapan P; Independent Researcher, Oxford, UK. Electronic address: praveenprathapan@hotmail.com.
Source:
European journal of medical genetics [Eur J Med Genet] 2025 Oct; Vol. 77, pp. 105041. Date of Electronic Publication: 2025 Aug 22.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101247089 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0849 (Electronic) Linking ISSN: 17697212 NLM ISO Abbreviation: Eur J Med Genet Subsets: MEDLINE
Imprint Name(s):
Original Publication: Amsterdam : Elsevier, c2005-
MeSH Terms:
Amino Acyl-tRNA Synthetases*/metabolism , Amino Acyl-tRNA Synthetases*/genetics , Genetic Code*, Humans ; RNA, Transfer/genetics ; RNA, Transfer/metabolism ; Amino Acids/genetics ; Amino Acids/metabolism
Contributed Indexing:
Keywords: Aminoacyl-tRNA synthetase; Biosemiotics; Enzymatic semiosis; Genetic code; Genetic semiosis; Semiosis
Substance Nomenclature:
EC 6.1.1.- (Amino Acyl-tRNA Synthetases)
9014-25-9 (RNA, Transfer)
0 (Amino Acids)
Entry Date(s):
Date Created: 20250824 Date Completed: 20250916 Latest Revision: 20250916
Update Code:
20250916
DOI:
10.1016/j.ejmg.2025.105041
PMID:
40850668
Database:
MEDLINE

Weitere Informationen

The genetic code is the set of rules by which nucleotide sequences correspond to amino acids. These rules are enforced by aminoacyl-tRNA synthetases (aaRSs): enzymes that ligate amino acids to tRNA molecules. Here it is argued this reaction suggests the genetic code may be understood as a 'code process'. Contrary to the prevailing adaptor model of the genetic code based on tRNAs, the semiotic model recognises a 'genetic code process' catalysed by aaRSs.
(Copyright © 2025 The Author. Published by Elsevier Masson SAS.. All rights reserved.)

Conflict of interest The authors declare no conflict of interest.