Treffer: Food and the brain: Neural and endocrine control of feeding, metabolism, and reproduction.
Title:
Food and the brain: Neural and endocrine control of feeding, metabolism, and reproduction.
Authors:
da Silva Mansano N; National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA., Lieu CV; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Abizaid A; Neuroscience Department, Carleton University, Ottawa, Ontario, Canada.
Source:
Journal of neuroendocrinology [J Neuroendocrinol] 2026 Jan; Vol. 38 (1), pp. e70104. Date of Electronic Publication: 2025 Oct 28.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Wiley & Sons Country of Publication: United States NLM ID: 8913461 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2826 (Electronic) Linking ISSN: 09538194 NLM ISO Abbreviation: J Neuroendocrinol Subsets: MEDLINE
Imprint Name(s):
Publication: <2010->: Malden, MA : Wiley & Sons
Original Publication: Eynsham, Oxon, UK : Oxford University Press, c1989-
Original Publication: Eynsham, Oxon, UK : Oxford University Press, c1989-
MeSH Terms:
References:
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Nitric Oxide. 2023 Feb 1;131:1-7. (PMID: 36513266)
J Clin Invest. 2006 Dec;116(12):3229-39. (PMID: 17060947)
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Horm Behav. 2018 Jan;97:56-66. (PMID: 29080670)
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J Neuroendocrinol. 2010 Jul;22(7):736-42. (PMID: 20646174)
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Neuroscience. 2011 Apr 28;180:129-37. (PMID: 21335062)
Int Rev Neurobiol. 2024;178:401-432. (PMID: 39523062)
Diabetes. 2014 Jul;63(7):2486-97. (PMID: 24608440)
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Addict Biol. 2006 Mar;11(1):45-54. (PMID: 16759336)
Endocrinology. 2023 Dec 23;165(2):. (PMID: 38170643)
Gastroenterology. 2017 May;152(7):1728-1738. (PMID: 28192106)
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J Neurosci. 1999 Feb 1;19(3):1072-87. (PMID: 9920670)
Curr Diab Rep. 2023 Mar;23(3):31-42. (PMID: 36752995)
Nat Rev Endocrinol. 2020 Aug;16(8):407-420. (PMID: 32427949)
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J Neuroendocrinol. 2009 Sep;21(9):787-93. (PMID: 19523165)
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Regul Pept. 2008 Aug 7;149(1-3):3-10. (PMID: 18514925)
N Engl J Med. 2022 Jul 21;387(3):205-216. (PMID: 35658024)
Nat Med. 2025 Mar;31(3):951-962. (PMID: 39833406)
Endocrinology. 2023 Sep 23;164(11):. (PMID: 37793082)
Nat Med. 2022 Oct;28(10):2083-2091. (PMID: 36216945)
Lancet. 2018 Nov 17;392(10160):2180-2193. (PMID: 30293770)
Obesity (Silver Spring). 2013 May;21(5):935-43. (PMID: 23408728)
Life Sci. 1984 Dec 24;35(26):2635-42. (PMID: 6549039)
Curr Opin Endocrinol Diabetes Obes. 2025 Jun 1;32(3):108-114. (PMID: 40125660)
Proc Natl Acad Sci U S A. 2000 May 23;97(11):6179-84. (PMID: 10811877)
Psychoneuroendocrinology. 2019 May;103:284-295. (PMID: 30771711)
Trends Endocrinol Metab. 1999 Aug;10(6):211-216. (PMID: 10407394)
Mol Metab. 2014 May 14;3(5):581-91. (PMID: 25061562)
Am J Physiol. 1997 Nov;273(5):E981-8. (PMID: 9374685)
Neuron. 2006 Sep 21;51(6):811-22. (PMID: 16982425)
Front Nutr. 2023 Oct 23;10:1241785. (PMID: 37937252)
Eur J Pharmacol. 1994 Dec 27;271(2-3):R11-3. (PMID: 7705422)
J Neuroendocrinol. 2026 Jan;38(1):e70104. (PMID: 41151834)
Physiol Behav. 2011 Sep 26;104(4):582-9. (PMID: 21549730)
Endocrinology. 2012 Nov;153(11):5587-99. (PMID: 22948210)
Obesity (Silver Spring). 2024 Mar;32(3):486-493. (PMID: 38053443)
Future Cardiol. 2016 Mar;12(2):129-38. (PMID: 26679384)
Metabolism. 1997 Dec;46(12):1384-9. (PMID: 9439531)
Eur J Pharmacol. 2009 Aug 1;615(1-3):113-7. (PMID: 19482021)
Cell Metab. 2023 Jun 6;35(6):979-995.e7. (PMID: 37201523)
Science. 2024 Jul 26;385(6707):438-446. (PMID: 38935778)
J Neuroendocrinol. 2022 Apr;34(4):e13126. (PMID: 35365872)
Cell Metab. 2006 Oct;4(4):275-82. (PMID: 17011500)
Int J Obes Relat Metab Disord. 2001 Dec;25 Suppl 5:S73-7. (PMID: 11840220)
Biol Reprod. 1985 Feb;32(1):1-26. (PMID: 3882162)
Diabetologia. 2023 Oct;66(10):1765-1779. (PMID: 36976349)
Cell Metab. 2015 Oct 6;22(4):741-9. (PMID: 26341832)
Mol Metab. 2019 Dec;30:72-130. (PMID: 31767182)
Elife. 2024 Jul 15;13:. (PMID: 39007235)
Diabetes Obes Metab. 2013 Jan;15(1):15-27. (PMID: 22776039)
Mol Cell Endocrinol. 2021 Dec 1;538:111449. (PMID: 34478806)
Front Neuroendocrinol. 2012 Aug;33(3):301-14. (PMID: 23000403)
Nat Med. 1995 Dec;1(12):1311-4. (PMID: 7489415)
Endocr Rev. 2006 Dec;27(7):736-49. (PMID: 17077189)
J Neuroendocrinol. 2000 Nov;12(11):1047-9. (PMID: 11069119)
Physiol Behav. 2018 Feb 1;184:211-219. (PMID: 29221808)
Bioorg Med Chem Lett. 2011 May 1;21(9):2641-5. (PMID: 21295475)
Nat Commun. 2019 Feb 8;10(1):662. (PMID: 30737388)
Cell Mol Life Sci. 2013 Mar;70(5):841-62. (PMID: 22851226)
Pharmacol Ther. 2022 Mar;231:107974. (PMID: 34530008)
Prog Neurobiol. 2009 Sep;89(1):18-45. (PMID: 19497349)
N Engl J Med. 2021 Mar 18;384(11):989-1002. (PMID: 33567185)
Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1792-8. (PMID: 17218439)
Psychoneuroendocrinology. 2015 Dec;62:392-402. (PMID: 26398679)
Mol Psychiatry. 2018 May;23(5):1157-1168. (PMID: 28894301)
Mol Cell Endocrinol. 2016 Mar 5;423:11-21. (PMID: 26762764)
Peptides. 1986 Nov-Dec;7(6):1189-92. (PMID: 3470711)
BMJ. 2020 Apr 1;369:m696. (PMID: 32238384)
Trends Pharmacol Sci. 2014 Jan;35(1):31-40. (PMID: 24332673)
Brain Res. 1995 Sep 4;690(2):185-8. (PMID: 8535835)
Front Nutr. 2022 Jun 24;9:891609. (PMID: 35811984)
J Neuroendocrinol. 2010 Jul;22(7):682-91. (PMID: 20492362)
Br J Pharmacol. 1998 Oct;125(3):549-55. (PMID: 9806339)
Endocrinology. 2022 Feb 1;163(2):. (PMID: 34953135)
Brain Res Mol Brain Res. 1997 Aug;48(1):23-9. (PMID: 9379845)
Neuron. 2006 Sep 21;51(6):801-10. (PMID: 16982424)
Neurosci Biobehav Rev. 2016 Jul;66:33-53. (PMID: 27136126)
Endocrinology. 2010 Jun;151(6):2736-46. (PMID: 20351316)
Nitric Oxide. 2023 Feb 1;131:1-7. (PMID: 36513266)
J Clin Invest. 2006 Dec;116(12):3229-39. (PMID: 17060947)
Mol Cell Endocrinol. 2010 Aug 5;324(1-2):82-6. (PMID: 20138117)
Horm Behav. 2018 Jan;97:56-66. (PMID: 29080670)
Mol Pharmacol. 2007 Feb;71(2):602-8. (PMID: 17105869)
J Neuroendocrinol. 2010 Jul;22(7):736-42. (PMID: 20646174)
J Neuroendocrinol. 2019 Jul;31(7):e12693. (PMID: 30714236)
Brain Res. 2003 Feb 21;964(1):107-15. (PMID: 12573518)
Int J Obes (Lond). 2009 Jun;33 Suppl 2:S8-13. (PMID: 19528982)
Neuroscience. 2011 Apr 28;180:129-37. (PMID: 21335062)
Int Rev Neurobiol. 2024;178:401-432. (PMID: 39523062)
Diabetes. 2014 Jul;63(7):2486-97. (PMID: 24608440)
Am J Clin Nutr. 2001 Nov;74(5):579-84. (PMID: 11684524)
Addict Biol. 2006 Mar;11(1):45-54. (PMID: 16759336)
Endocrinology. 2023 Dec 23;165(2):. (PMID: 38170643)
Gastroenterology. 2017 May;152(7):1728-1738. (PMID: 28192106)
Physiol Behav. 2004 Apr;81(2):289-317. (PMID: 15159173)
Horm Behav. 2016 Feb;78:141-9. (PMID: 26592452)
Endocrinology. 2001 Dec;142(12):5294-302. (PMID: 11713229)
J Neurosci. 1999 Feb 1;19(3):1072-87. (PMID: 9920670)
Curr Diab Rep. 2023 Mar;23(3):31-42. (PMID: 36752995)
Nat Rev Endocrinol. 2020 Aug;16(8):407-420. (PMID: 32427949)
J Sex Med. 2018 Jan;15(1):20-28. (PMID: 29289371)
J Neuroendocrinol. 2009 Sep;21(9):787-93. (PMID: 19523165)
J Reprod Immunol. 2025 Jun;169:104538. (PMID: 40359784)
Front Neurosci. 2019 Nov 26;13:1280. (PMID: 31849590)
Physiol Behav. 1984 Jun;32(6):923-7. (PMID: 6494309)
Reproduction. 2014 Feb 03;147(3):R53-63. (PMID: 24327738)
eNeuro. 2024 Jul 16;11(7):. (PMID: 38937108)
Peptides. 2005 Nov;26(11):2274-9. (PMID: 16137788)
Hum Reprod Update. 2019 Jul 1;25(4):504-517. (PMID: 31260047)
Front Endocrinol (Lausanne). 2011 Oct 25;2:57. (PMID: 22649378)
J Endocrinol. 2021 Mar;248(3):325-335. (PMID: 33446613)
Neuropsychopharmacology. 2018 Feb;43(3):607-616. (PMID: 28857071)
Cell Death Dis. 2016 May 26;7:e2237. (PMID: 27228352)
Mol Metab. 2016 Aug 11;5(10):844-857. (PMID: 27688998)
Front Neurosci. 2022 Jul 27;16:953252. (PMID: 35968365)
Neuropsychopharmacology. 2016 Jun;41(7):1917-28. (PMID: 26675243)
J Neurosci. 2024 May 22;44(21):. (PMID: 38575343)
Front Cell Neurosci. 2016 Sep 12;10:214. (PMID: 27672360)
Mol Neurobiol. 2019 Feb;56(2):769-796. (PMID: 29796992)
Trends Endocrinol Metab. 2010 Jan;21(1):10-6. (PMID: 19854659)
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2413-2418. (PMID: 28196880)
Exp Neurol. 2019 Oct;320:113006. (PMID: 31279911)
Curr Opin Endocrinol Diabetes Obes. 2013 Aug;20(4):335-41. (PMID: 23807606)
Nature. 1996 Jul 18;382(6588):250-2. (PMID: 8717038)
Horm Behav. 2011 Nov;60(5):572-80. (PMID: 21872601)
Horm Behav. 2023 Sep;155:105412. (PMID: 37633226)
Clin Nutr ESPEN. 2022 Aug;50:63-73. (PMID: 35871953)
Brain Struct Funct. 2024 Dec 19;230(1):15. (PMID: 39702649)
Endocrinology. 1998 Nov;139(11):4634-41. (PMID: 9794475)
Brain Res. 2016 Aug 15;1645:68-70. (PMID: 26731335)
Endocrinology. 2015 Nov;156(11):4226-37. (PMID: 26252058)
Regul Pept. 2008 Aug 7;149(1-3):3-10. (PMID: 18514925)
N Engl J Med. 2022 Jul 21;387(3):205-216. (PMID: 35658024)
Nat Med. 2025 Mar;31(3):951-962. (PMID: 39833406)
Endocrinology. 2023 Sep 23;164(11):. (PMID: 37793082)
Nat Med. 2022 Oct;28(10):2083-2091. (PMID: 36216945)
Lancet. 2018 Nov 17;392(10160):2180-2193. (PMID: 30293770)
Obesity (Silver Spring). 2013 May;21(5):935-43. (PMID: 23408728)
Life Sci. 1984 Dec 24;35(26):2635-42. (PMID: 6549039)
Curr Opin Endocrinol Diabetes Obes. 2025 Jun 1;32(3):108-114. (PMID: 40125660)
Proc Natl Acad Sci U S A. 2000 May 23;97(11):6179-84. (PMID: 10811877)
Psychoneuroendocrinology. 2019 May;103:284-295. (PMID: 30771711)
Trends Endocrinol Metab. 1999 Aug;10(6):211-216. (PMID: 10407394)
Mol Metab. 2014 May 14;3(5):581-91. (PMID: 25061562)
Am J Physiol. 1997 Nov;273(5):E981-8. (PMID: 9374685)
Neuron. 2006 Sep 21;51(6):811-22. (PMID: 16982425)
Front Nutr. 2023 Oct 23;10:1241785. (PMID: 37937252)
Eur J Pharmacol. 1994 Dec 27;271(2-3):R11-3. (PMID: 7705422)
J Neuroendocrinol. 2026 Jan;38(1):e70104. (PMID: 41151834)
Physiol Behav. 2011 Sep 26;104(4):582-9. (PMID: 21549730)
Endocrinology. 2012 Nov;153(11):5587-99. (PMID: 22948210)
Obesity (Silver Spring). 2024 Mar;32(3):486-493. (PMID: 38053443)
Future Cardiol. 2016 Mar;12(2):129-38. (PMID: 26679384)
Metabolism. 1997 Dec;46(12):1384-9. (PMID: 9439531)
Eur J Pharmacol. 2009 Aug 1;615(1-3):113-7. (PMID: 19482021)
Cell Metab. 2023 Jun 6;35(6):979-995.e7. (PMID: 37201523)
Science. 2024 Jul 26;385(6707):438-446. (PMID: 38935778)
J Neuroendocrinol. 2022 Apr;34(4):e13126. (PMID: 35365872)
Cell Metab. 2006 Oct;4(4):275-82. (PMID: 17011500)
Int J Obes Relat Metab Disord. 2001 Dec;25 Suppl 5:S73-7. (PMID: 11840220)
Biol Reprod. 1985 Feb;32(1):1-26. (PMID: 3882162)
Diabetologia. 2023 Oct;66(10):1765-1779. (PMID: 36976349)
Cell Metab. 2015 Oct 6;22(4):741-9. (PMID: 26341832)
Mol Metab. 2019 Dec;30:72-130. (PMID: 31767182)
Elife. 2024 Jul 15;13:. (PMID: 39007235)
Diabetes Obes Metab. 2013 Jan;15(1):15-27. (PMID: 22776039)
Mol Cell Endocrinol. 2021 Dec 1;538:111449. (PMID: 34478806)
Front Neuroendocrinol. 2012 Aug;33(3):301-14. (PMID: 23000403)
Nat Med. 1995 Dec;1(12):1311-4. (PMID: 7489415)
Endocr Rev. 2006 Dec;27(7):736-49. (PMID: 17077189)
J Neuroendocrinol. 2000 Nov;12(11):1047-9. (PMID: 11069119)
Physiol Behav. 2018 Feb 1;184:211-219. (PMID: 29221808)
Bioorg Med Chem Lett. 2011 May 1;21(9):2641-5. (PMID: 21295475)
Nat Commun. 2019 Feb 8;10(1):662. (PMID: 30737388)
Cell Mol Life Sci. 2013 Mar;70(5):841-62. (PMID: 22851226)
Pharmacol Ther. 2022 Mar;231:107974. (PMID: 34530008)
Prog Neurobiol. 2009 Sep;89(1):18-45. (PMID: 19497349)
N Engl J Med. 2021 Mar 18;384(11):989-1002. (PMID: 33567185)
Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1792-8. (PMID: 17218439)
Psychoneuroendocrinology. 2015 Dec;62:392-402. (PMID: 26398679)
Mol Psychiatry. 2018 May;23(5):1157-1168. (PMID: 28894301)
Mol Cell Endocrinol. 2016 Mar 5;423:11-21. (PMID: 26762764)
Peptides. 1986 Nov-Dec;7(6):1189-92. (PMID: 3470711)
BMJ. 2020 Apr 1;369:m696. (PMID: 32238384)
Trends Pharmacol Sci. 2014 Jan;35(1):31-40. (PMID: 24332673)
Brain Res. 1995 Sep 4;690(2):185-8. (PMID: 8535835)
Front Nutr. 2022 Jun 24;9:891609. (PMID: 35811984)
J Neuroendocrinol. 2010 Jul;22(7):682-91. (PMID: 20492362)
Br J Pharmacol. 1998 Oct;125(3):549-55. (PMID: 9806339)
Endocrinology. 2022 Feb 1;163(2):. (PMID: 34953135)
Brain Res Mol Brain Res. 1997 Aug;48(1):23-9. (PMID: 9379845)
Neuron. 2006 Sep 21;51(6):801-10. (PMID: 16982424)
Neurosci Biobehav Rev. 2016 Jul;66:33-53. (PMID: 27136126)
Endocrinology. 2010 Jun;151(6):2736-46. (PMID: 20351316)
Grant Information:
ZIA NS002824 United States ImNIH Intramural NIH HHS; Natural Sciences and Engineering Research Council of Canada; PJT - 178087 Canada CAPMC CIHR; ZIA NS002824-33 United States NS NINDS NIH HHS
Contributed Indexing:
Keywords: GnRH; energy balance; ghrelin; leptin; reproduction
Substance Nomenclature:
0 (Leptin)
Entry Date(s):
Date Created: 20251028 Date Completed: 20260114 Latest Revision: 20260116
Update Code:
20260116
PubMed Central ID:
PMC12799328
DOI:
10.1111/jne.70104
PMID:
41151834
Database:
MEDLINE
Weitere Informationen
Feeding and reproductive function are regulated by intricate systems that monitor food availability and energy stores, and on the basis of energy status, promote or put a brake on reproduction. This is particularly evident in the systems that regulate feeding and reproductive state in female mammals. Here we describe some of the systems that regulate feeding and reproductive state focusing on how metabolic hormones impact the onset of puberty as discussed in the panel session presented at the recent Panamerican Neuroendocrine Society meeting in Santos, Brazil. Indeed, hormones like leptin and insulin, which are released when levels of energy resources are increasing, may be critical signals that activate hypothalamic pathways related to ovulation in females to cause the onset of puberty. In adults, increasing levels of these hormones signal to the hypothalamus to reduce food intake and increase energy expenditure. In contrast, hormones like ghrelin impact hypothalamic and extrahypothalamic brain regions to drive hunger and the motivation to eat ultimately increasing feeding behavior and decreasing energy expenditure. Based on these actions, we describe some potential targets for the treatment of obesity and the mechanisms by which these targets work to improve human health.
(© 2025 The Author(s). Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.)