• Multimodal therapy process eng...

Treffer: Multimodal therapy process engineering mediated by 3D-printed scaffolds for enhanced postoperative osteosarcoma regeneration.

Title:
Multimodal therapy process engineering mediated by 3D-printed scaffolds for enhanced postoperative osteosarcoma regeneration.
Authors:
Liu X; Cancer Hospital of Dalian University of Technology, State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China., Xu J; Cancer Hospital of Dalian University of Technology, State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China., Zhu J; Cancer Hospital of Dalian University of Technology, State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China., Wang Z; Cancer Hospital of Dalian University of Technology, State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China., Fang H; Cancer Hospital of Dalian University of Technology, State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China., Guo W; Cancer Hospital of Dalian University of Technology, State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China., Cao L; Cancer Hospital of Dalian University of Technology, State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China., Cheng YY; Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology Sydney, NSW 2007, Australia., Song K; Cancer Hospital of Dalian University of Technology, State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China; Key Laboratory of Biotechnology and Bioresources Utilization of Ministry of Education, Dalian Minzu University, Dalian 116600, China. Electronic address: Kedongsong@dlut.edu.cn.
Source:
Tissue & cell [Tissue Cell] 2026 Feb; Vol. 98, pp. 103212. Date of Electronic Publication: 2025 Oct 31.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE
Imprint Name(s):
Publication: Edinburgh : Churchill Livingstone
Original Publication: Edinburgh, Oliver & Boyd.
MeSH Terms:
Osteosarcoma*/therapy , Osteosarcoma*/pathology , Printing, Three-Dimensional* , Tissue Scaffolds*/chemistry , Tissue Engineering*/methods , Bone Regeneration* , Bone Neoplasms*/therapy, Humans ; Combined Modality Therapy ; Animals
Contributed Indexing:
Keywords: 3D printed scaffolds; Anti-tumor; Bone regeneration; Multimodal therapy; Osteosarcoma
Entry Date(s):
Date Created: 20251104 Date Completed: 20251216 Latest Revision: 20251224
Update Code:
20251224
DOI:
10.1016/j.tice.2025.103212
PMID:
41187387
Database:
MEDLINE

Weitere Informationen

The clinical management of osteosarcoma post-resection presents a persistent dual challenge: reconstructing critical-sized bone defects while preventing local tumor recurrence. 3D printed scaffolds have emerged as a precision engineering solution, leveraging their patient-specific design capabilities and rapid manufacturability to address these competing demands. This comprehensive minireview examines current advances in 3D printed scaffold systems functionalized with multimodal therapeutic approaches-encompassing chemotherapy, photothermal therapy (PTT), magnetothermal therapy (MTT), immunotherapy, chemodynamic therapy (CDT), and photodynamic therapy (PDT) - for synergistic postoperative management. Through analysis of the mechanisms and synergistic effects of these therapeutic approaches, the multifunctional roles of 3D printed scaffolds in drug delivery, tumor suppression, and bone regeneration are discussed. Future development of intelligent and personalized 3D-printed scaffolds is expected to accelerate clinical translation for post-osteosarcoma reconstruction.
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