Treffer: Surgical Implantation of a Wireless System for Portal Vein Pressure Monitoring in a Chronic Fontan Ovine Model.

Title:
Surgical Implantation of a Wireless System for Portal Vein Pressure Monitoring in a Chronic Fontan Ovine Model.
Authors:
Guo M; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital; Department of Surgery, The Ohio State University Wexner Medical Center; marissa.guo1@nationwidechildrens.org., Watanabe T; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital., DeShetler C; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital., Kievert J; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital; Biomedical Sciences Graduate Program, The Ohio State University College of Medicine., Yuhara S; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital., Matsuda J; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital., Morrison A; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital., Nelson K; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital., Heuer E; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital., Taha F; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital., Nathan JD; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital; Department of Pediatric Surgery, Nationwide Children's Hospital., Kelly JM; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital; Department of Pediatric Cardiology, Nationwide Children's Hospital., Breuer CK; Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital; Department of Pediatric Surgery, Nationwide Children's Hospital.
Source:
Journal of visualized experiments : JoVE [J Vis Exp] 2025 Oct 24 (224). Date of Electronic Publication: 2025 Oct 24.
Publication Type:
Journal Article; Video-Audio Media
Language:
English
Journal Info:
Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE
Imprint Name(s):
Original Publication: [Boston, Mass. : MYJoVE Corporation, 2006]-
MeSH Terms:
Fontan Procedure*/methods , Portal Vein*/surgery , Portal Vein*/physiology , Telemetry*/methods , Telemetry*/instrumentation , Portal Pressure*/physiology, Animals ; Sheep
Entry Date(s):
Date Created: 20251110 Date Completed: 20251112 Latest Revision: 20251112
Update Code:
20251113
DOI:
10.3791/68936
PMID:
41212852
Database:
MEDLINE

Weitere Informationen

The Fontan circulation is characterized by nonpulsatile pulmonary blood flow and chronic systemic venous congestion, which has been associated with several late-term complications, including Fontan-associated liver disease (FALD). Chronic animal models are a valuable tool for studying the pathophysiology underlying such disease processes. However, obtaining hemodynamic data from freely moving large animals poses several challenges. The use of wireless implantable telemetry systems may provide a novel means of acquiring pressure measurements from the hepatic circulation in real time. The following protocol describes the surgical methodology for wireless telemetry device implantation with cannulation of the portal vein in a Fontan ovine model, enabling the continuous and long-term collection of portal venous pressures and facilitating future investigations into the hemodynamic changes associated with chronic liver disease in Fontan patients.