• Three-dimensional volumetric a...

Treffer: Three-dimensional volumetric analysis of bone volume change in grade II mandibular furcation defects: A CBCT-based methodological study.

Title:
Three-dimensional volumetric analysis of bone volume change in grade II mandibular furcation defects: A CBCT-based methodological study.
Authors:
Chatzopoulos GS; School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece; Division of Periodontology, School of Dentistry, University of Minnesota, USA. Electronic address: chatz005@umn.edu., Makrygiannakis MA; School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece; School of Dentistry, European University Cyprus, Nicosia, Cyprus., Tsalikis L; School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece., Kaklamanos EG; School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece; School of Dentistry, European University Cyprus, Nicosia, Cyprus; Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, , United Arab Emirates.
Source:
Journal of dentistry [J Dent] 2026 Jan; Vol. 164, pp. 106236. Date of Electronic Publication: 2025 Nov 14.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Elsevier Country of Publication: England NLM ID: 0354422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-176X (Electronic) Linking ISSN: 03005712 NLM ISO Abbreviation: J Dent Subsets: MEDLINE
Imprint Name(s):
Publication: Kidlington : Elsevier
Original Publication: Bristol, Eng., Wright.
MeSH Terms:
Cone-Beam Computed Tomography*/methods , Cone-Beam Computed Tomography*/statistics & numerical data , Furcation Defects*/diagnostic imaging , Furcation Defects*/pathology , Furcation Defects*/therapy , Imaging, Three-Dimensional*/methods , Imaging, Three-Dimensional*/statistics & numerical data , Mandible*/diagnostic imaging , Mandible*/pathology , Alveolar Process*/diagnostic imaging , Alveolar Process*/pathology , Mandibular Diseases*/diagnostic imaging, Humans ; Reproducibility of Results ; Male ; Middle Aged ; Observer Variation ; Female ; Adult ; Guided Tissue Regeneration, Periodontal/methods ; Alveolar Bone Loss/diagnostic imaging ; Proof of Concept Study ; Image Processing, Computer-Assisted/methods ; Image Processing, Computer-Assisted/statistics & numerical data ; Follow-Up Studies ; Bone Regeneration/physiology
Contributed Indexing:
Keywords: Cone-beam computed tomography; Furcation defects; Methodology; Periodontitis; Reliability Study; Volumetric analysis
Entry Date(s):
Date Created: 20251116 Date Completed: 20251208 Latest Revision: 20251208
Update Code:
20251209
DOI:
10.1016/j.jdent.2025.106236
PMID:
41242649
Database:
MEDLINE

Weitere Informationen

Objective: To establish and assess the inter- and intra-rater reliability of a novel, semi-automated protocol for three-dimensional (3D) volumetric analysis of bone volume changes in mandibular Grade II furcation defects using Cone-Beam Computed Tomography (CBCT).
Methods: The reliability of this methodological proof-of-concept study was the primary endpoint. Inter- and intra-rater agreement were rigorously assessed on a substantial dataset of 100 Regions of Interest (ROIs) by two examiners using the Bland-Altman method and the Intraclass Correlation Coefficient (ICC). The protocol utilized automatically segmented STL files from high-resolution CBCT scans. Following ratification, the protocol was applied on an exploratory basis only to an illustrative subset of 13 defects to demonstrate its clinical application in calculating volumetric bone differences at different timepoints of observation; specifically, at baseline and nine months later, following regenerative periodontal therapy(ΔV = V₉-V₀).
Results: The volumetric measurement protocol demonstrated excellent reliability. The inter-rater and intra-rater ICC values were both >0.99 (p < 0.001). Bland-Altman analysis showed narrow limits of agreement and no significant systematic differences between or within examiners (p > 0.05). In the preliminary patient subset, the calculated volumetric bone difference (ΔV) ranged from -33.01 mm³ to 8.93 mm³.
Conclusion: This study successfully established a highly reliable, semi-automated method for the 3D volumetric analysis of alveolar bone changes in furcation defects due to periodontal treatment or progress of periodontal disease.
Clinical Significance: This ratified, non-invasive protocol provides a precise and objective tool for quantifying hard tissue changes following periodontal regenerative therapy. By overcoming the limitations of traditional 2D methods and subjective clinical probing, it can significantly enhance the accuracy and objectivity of future clinical research in periodontal regeneration.
(Copyright © 2025 Elsevier Ltd. All rights reserved.)

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.