• Codon Usage Bias Analysis of C...

Treffer: Codon Usage Bias Analysis of Citrus Leaf Blotch Virus.

Title:
Codon Usage Bias Analysis of Citrus Leaf Blotch Virus.
Authors:
Ren X; College of Life Science, Gannan Normal University, Ganzhou 341000, China., Xu L; College of Life Science, Gannan Normal University, Ganzhou 341000, China., Yan Y; College of Life Science, Gannan Normal University, Ganzhou 341000, China., Wang Y; College of Life Science, Gannan Normal University, Ganzhou 341000, China., Huang A; College of Life Science, Gannan Normal University, Ganzhou 341000, China.; National Navel Orange Engineering Research Center, Ganzhou 341000, China.
Source:
Viruses [Viruses] 2025 Nov 12; Vol. 17 (11). Date of Electronic Publication: 2025 Nov 12.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI
MeSH Terms:
Codon Usage* , Plant Diseases*/virology , Citrus*/virology , Flexiviridae*/genetics , Flexiviridae*/classification, Phylogeny ; Genome, Viral ; Selection, Genetic ; Genetic Variation ; Codon
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Grant Information:
32460646 National Natural Science Foundation of China
Contributed Indexing:
Keywords: citrus leaf blotch virus; codon usage; host adaptation
Substance Nomenclature:
0 (Codon)
Entry Date(s):
Date Created: 20251127 Date Completed: 20251127 Latest Revision: 20251130
Update Code:
20251130
PubMed Central ID:
PMC12656731
DOI:
10.3390/v17111497
PMID:
41305517
Database:
MEDLINE

Weitere Informationen

Citrus leaf blotch virus (CLBV) is a positive-sense single-stranded RNA virus belonging to the genus Citrivirus within the family Betaflexiviridae . It infects a broad range of economically significant fruit crops, including citrus, kiwifruit, and apple. Surveys conducted in the field have documented appreciable incidence rates in several hosts, thereby emphasizing its emerging threat to global pomiculture. Comprehensive surveillance of CLBV genetic diversity is indispensable for predicting strain-specific epidemics and designing durable, broadly protective control strategies. Current surveys of CLBV diversity are still gene-fragment-centric, with whole-genome resolution remaining largely untapped. In this study, an analysis of codon usage bias analysis was performed using all available CLBV full-length genomes. The findings revealed that CLBV exhibits low codon usage bias, with natural selection, rather than mutational drift, being the primary driver. Phylogenetic analysis has been demonstrated to categorize isolates according to their host of origin rather than their geographical location. This observation suggests that host adaptation may supersede spatial structure in CLBV evolution and reinforce natural selection as the dominant force shaping its codon usage landscape. From the perspective of the codon adaptation index, Prunus avium is the host that exerts the greatest influence on the formation of its codon usage bias. The present study provides the first genome-wide portrait of CLBV codon usage bias, offering a robust framework for future investigations into its origin and evolutionary dynamics.