Treffer: Surface dosimetry in Re-188 therapy: A new approach based on image processing and comparison with VARSKIN software.

Introduction: Accurate dosimetry calculations are crucial for effective surface radiopharmaceutical therapy. This study presents a novel computational method for determining key parameters such as initial activity (A0), skin dose (D_skin), and treatment time (T_calc). The method integrates image-based tumor surface detection, scale calibration, and automated segmentation for precise area estimation. Methods: The proposed approach incorporates depth-dependent correction factors, improving accuracy beyond VARSKIN software. Implemented in Python, it employs OpenCV and PyQt6 for image processing, optimizing dosimetric parameter calculations while reducing errors. Results: Comparative analysis shows high accuracy, with discrepancies below 7% for treatment time and skin dose Conclusion: Key advantages include enhanced precision in tumor area estimation, automated dose calculation, and improved usability. Future work will focus on extending the model for cumulative dose calculations and dose distribution analysis. This study contributes to advancements in computational dosimetry for Rhenium-188 therapy, improving treatment planning and patient outcomes. [ABSTRACT FROM AUTHOR]

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