Treffer: 13CFLUX - third-generation high-performance engine for isotopically (non)stationary 13C metabolic flux analysis Open Access.
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Summary <sup>13</sup>C-based metabolic flux analysis is a cornerstone of quantitative systems biology, yet its increasing data complexity and methodological diversity place high demands on simulation software. We introduce 13CFLUX (v3), a third-generation simulation platform that combines a high-performance C++ engine with a convenient Python interface. The software delivers substantial performance gains across isotopically stationary and nonstationary analysis workflows, while remaining flexible to accommodate diverse labeling strategies and analytical platforms. Its open-source availability facilitates seamless integration into computational ecosystems and community-driven extension. By supporting multi-experiment integration, multi-tracer studies, and advanced statistical inference such as Bayesian analysis, 13CFLUX provides a robust and extensible framework for modern fluxomics research. Availability and implementation Sources and containers are provided at https://jugit.fz-juelich.de/IBG-1/ModSim/Fluxomics/13CFLUX , and scripts to replicate results in the supplementary data at https://github.com/JuBiotech/Supplement-to-Stratmann-et-al.-Bioinformatics-2025. [ABSTRACT FROM AUTHOR]
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