Treffer: Bootstrap Evaluation of Association Matrices (BEAM) for Integrating Multiple Omics Profiles with Multiple Outcomes.

The article discusses a statistical method called Bootstrap Evaluation of Association Matrices (BEAM) that integrates multiple omics profiles with multiple clinical endpoints. BEAM associates omic features with clinical endpoints using regression models and determines the statistical significance of the set through bootstrap resampling. The method has been shown to outperform other integrated analysis methods and has identified genes with biological relevance in a pediatric leukemia application. The source code, documentation, and a vignette for BEAM are available on GitHub, and the R package is available from CRAN. [Extracted from the article]