Treffer: FASN-dependent de novo lipogenesis is required for brain development

Title:
FASN-dependent de novo lipogenesis is required for brain development
Authors:
Gonzalez-Bohorquez, Daniel, Gallego López, Isabel M, Jaeger, Baptiste N, Pfammatter, Sibylle, Bowers, Megan, Semenkovich, Clay F, Jessberger, Sebastian
Contributors:
University of Zurich, Jessberger, Sebastian
Source:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, 119 (2)
PNAS
Publisher Information:
Proceedings of the National Academy of Sciences, 2022.
Publication Year:
2022
Subject Terms:
0301 basic medicine, 610 Medicine & health, 10071 Functional Genomics Center Zurich, Mice, neural stem cell, 03 medical and health sciences, Neural Stem Cells, U9 Adaptive Brain Circuits in Development and Learning (AdaBD), Animals, Humans, polarity, lipogenesis, Body Patterning, Mice, Knockout, 1000 Multidisciplinary, Multidisciplinary, 10242 Brain Research Institute, Lipogenesis, Brain, Biological Sciences, Lipid Metabolism, Fatty Acid Synthase, Type I, neurogenesis, 570 Life sciences, biology, 590 Animals (Zoology), Fatty Acid Synthases, Transcriptome, Neuroglia
Document Type:
Fachzeitschrift Article<br />Other literature type
File Description:
application/application/pdf; ZORA_viewcontent_cgi_article_12151.pdf - application/pdf; application/pdf
Language:
English
ISSN:
1091-6490
0027-8424
DOI:
10.1073/pnas.2112040119
DOI:
10.3929/ethz-b-000527081
DOI:
10.5167/uzh-219581
Access URL:
https://www.pnas.org/content/pnas/119/2/e2112040119.full.pdf
https://pubmed.ncbi.nlm.nih.gov/34996870
http://hdl.handle.net/20.500.11850/527081
https://www.zora.uzh.ch/id/eprint/219581/
https://doi.org/10.5167/uzh-219581
Rights:
CC BY
URL: http://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
Accession Number:
edsair.doi.dedup.....06f1972e69732c7e9a951c8aaab4e62c
Database:
OpenAIRE

Weitere Informationen

Significance Regulation of cellular metabolism in proliferating progenitor cells and their neuronal progeny is critical for brain development and function. Here, we identify a pivotal role of fatty acid synthase (FASN)-dependent de novo lipogenesis for mouse and human brain development, as genetic deletion of FASN leads to microcephaly in the developing mouse cortex and cortical malformations in human embryonic stem cell–derived forebrain organoids. Mechanistically, we show that FASN is required for proper polarity of apical progenitor cells. The dual approach applied here, using mouse genetics and human forebrain organoids, establishes a role of FASN-dependent lipogenesis for mouse and human brain development and identifies a link between progenitor-cell polarity and lipid metabolism.