Treffer: The relevance of creating a new combination drug for the treatment of cognitive disorders

Cognitive impairment is one of the most pressing problems of modern medicine, as its prevalence is steadily increasing worldwide. This trend is due to several global factors, including population aging, urbanization, the spread of chronic diseases, as well as the impact of the COVID-19 pandemic. Stress and social factors play a special role in the growth of cognitive disorders, which in recent years have significantly increased their impact on the population. In Ukraine, the problem of cognitive disorders has become even more acute due to socio-economic challenges and the consequences of the military aggression of the Russian Federation. Constant stress, loss of loved ones, forced displacement and a general sense of danger significantly affect cognitive functions, such as memory, concentration and planning ability. Understanding the basic mechanisms of the development of cognitive disorders is key to developing effective therapeutic approaches. Current research demonstrates that key pathogenetic factors include neurodegeneration, vascular disorders, metabolic dysfunction, and the effects of chronic stress. This emphasizes the need to develop new combination drugs that could comprehensively affect several pathogenetic links. Aim. Analysis and systematization of current data on the mechanisms of development of cognitive disorders, as well as determination, based on the results of the analysis, of the most promising directions for the development of new drugs aimed at restoring and supporting cognitive functions. Materials and methods. Data from sources of professional literature presented in international bibliographic databases (Web of Science, Scopus, PubMed, Chemical Abstracts) were used as the object of research. Methods of system analysis and information search were used. In the process of work, a bibliosemantic approach was used to analyze the relationship between key topics and research areas, as well as descriptive and generalized analysis methods to form conclusions about the current state and promising directions for the development of drugs for the treatment of cognitive disorders. Results. Trend analysis showed a significant increase in cases of cognitive disorders both in the world and in Ukraine, which is associated with global factors of population aging, stress factors and neurodegenerative diseases. In Ukraine, this problem is exacerbated by socio-economic conditions and the consequences of armed aggression. Key mechanisms of cognitive disorders have been established, including neurodegeneration, vascular disorders and metabolic dysfunction. Based on these data, the prospects for the development of a new combined drug containing sodium succinate and dimethylaminoethanol for an effective impact on pathogenetic mechanisms, improving neuroprotection and supporting cognitive functions have been determined. Conclusions. The review of current scientific literature devoted to the study of the causes of cognitive disorders reflects the current state of research in this area. A few scientific works emphasize the importance of finding more effective approaches to restoring cognitive functions, which emphasizes the high potential for the development of new therapeutic agents. This proves the promise of creating combination drugs that could affect several key mechanisms contributing to the development of cognitive disorders.