Treffer: JCell : a Java framework for inferring genetic networks

JCell is a framework for reconstructing and simulating genetic networks in the field of molecular biology. It is completely implemented in Java. The main goal of JCell is to gain deep insights of molecular processes within a cell or tissue under various conditions such as drug concentrations or pathogenic mutations. This question has recently become a major area of research in the field of bioinformatics, because understanding the regulating dependencies enables new therapies of diseases like cancer or Alzheimer. To address the mentioned inference problem, several mathematical models and algorithms have been developed and implemented, which try to infer genetic relationships from genomic experiment data. The program consists of a modular structure, which enables users to utilize the framework also in other research areas such as metabolic pathway reconstruction, signalling cascade analysis or general biochemical processes. Further on, JCell can also be used in other contexts to identify dynamic systems from time series data such as financial applications or engineering problems. Usability was always the primary focus during development, so that even users without a strong computer science background are able to use the program. Another focus was the ability of JCell to natively import as much file formats as possible to be compatible with the most commonly used analysis tools. Due to the usage of the programming language Java, the framework is platform independent and thus able to work on most hardware/software systems. This is especially important for those research facilities where no expensive hardware can purchased and where no restrictions for the used operating systems can be implied. Further more, the framework is open to public development and new modules can be easily implemented. ; JCell ist ein komplett in Java realisiertes Framework zur Rekonstruktion und Simulation von genetischen Netzwerken in verschiedenen Bereichen der Molekularbiologie. Ziel ist die eingehende Untersuchung von Abläufen innerhalb ...