Result: On-chip antibody handling and colorimetric detection in a magnetic droplet manipulation system

Title:
On-chip antibody handling and colorimetric detection in a magnetic droplet manipulation system
Authors:
LEHMANN, U, DE COURTEN, D, VANDEVYVER, C, PARASHAR, V. K, GIJS, M. A. M
Source:
Proceedings of the 32nd International Conference on Micro- and Nano-Engineering, Barcelona, 17-20 September 2006Microelectronic engineering. 84(5-8):1669-1672
Publisher Information:
Amsterdam: Elsevier Science, 2007.
Publication Year:
2007
Physical Description:
print, 10 ref
Original Material:
INIST-CNRS
Subject Terms:
Electronics, Electronique, Sciences exactes et technologie, Exact sciences and technology, Physique, Physics, Domaines classiques de la physique (y compris les applications), Fundamental areas of phenomenology (including applications), Mécanique des fluides, Fluid dynamics, Mécanique des fluides appliquée, Applied fluid mechanics, Fluidique, Fluidics, Sciences appliquees, Applied sciences, Electronique, Electronics, Electronique des semiconducteurs. Microélectronique. Optoélectronique. Dispositifs à l'état solide, Semiconductor electronics. Microelectronics. Optoelectronics. Solid state devices, Circuits intégrés, Integrated circuits, Conception. Technologies. Analyse fonctionnement. Essais, Design. Technologies. Operation analysis. Testing, Circuit intégré, Integrated circuit, Circuito integrado, Microfluidique, Microfluidics, Microparticule, Microparticle, Micropartícula, Miniaturisation, Miniaturization, Miniaturización, Système sur puce, System on a chip, Sistema sobre pastilla, Temps réaction, Reaction time, Tiempo reacción, 4785N, Droplets, Lab-on-a-chip, Magnetic microparticles
Document Type:
Conference Conference Paper
File Description:
text
Language:
English
Author Affiliations:
Institute of Microelectronics and Microsystems (Station 17), Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Research Commission EPFL-SNF, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland
ISSN:
0167-9317
Access URL:
http://pascal-francis.inist.fr/vibad/index.php?action=search&terms=18807520
Rights:
Copyright 2007 INIST-CNRS
CC BY 4.0
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Notes:
Electronics

Physics: fluid mechanics
Accession Number:
edscal.18807520
Database:
PASCAL Archive

Further Information

Miniaturized system for bioanalysis have been constantly gaining importance and interest within the recent years. The reduction of sample consumption and reaction time are some of the major advantages of such lab-on-a-chip applications. One of the greatest challenges in these systems is the handling of small sample volumes. A possible way is to manipulate such volumes in the form of small droplets. This work demonstrates the potential of a modular magnetic droplet manipulation system for its application in bioanalysis. We studied the parameters of the droplet manipulation, and their application for the on-chip detection of an enzyme labeled antibody. By using sample volumes of μl size we are able to detect quantities in the pg-range of enzyme labeled antibodies, which is the first step to a miniaturized immunoassay on a chip.