Result: Toward SQUID-based direct measurement of neural currents by nuclear magnetic resonance

Title:
Toward SQUID-based direct measurement of neural currents by nuclear magnetic resonance
Authors:
KRAUS, Robert H, ESPY, Michelle A, VOLEGOV, Petr L, MATLACHOV, Andrei N, MOSHER, John C, URBAITIS, Algis V, ZOTEV, Vadim S
Source:
The 2006 applied superconductivity conference, Seattle, WA, August 27-September 1, 2006IEEE transactions on applied superconductivity. 17(2):854-857
Publisher Information:
New York, NY: Institute of Electrical and Electronics Engineers, 2007.
Publication Year:
2007
Physical Description:
print, 17 ref 1
Original Material:
INIST-CNRS
Subject Terms:
Electronics, Electronique, Electrical engineering, Electrotechnique, Sciences exactes et technologie, Exact sciences and technology, Sciences appliquees, Applied sciences, Electronique, Electronics, Electronique des semiconducteurs. Microélectronique. Optoélectronique. Dispositifs à l'état solide, Semiconductor electronics. Microelectronics. Optoelectronics. Solid state devices, Dispositifs supraconducteurs, Superconducting devices, Biomagnétisme, Biomagnetism, Champ extérieur, External field, Campo exterior, Champ intense, High field, Campo intenso, Champ magnétique, Magnetic field, Campo magnético, Dispositif supraconducteur quantique, Superconducting quantum interferometer device, Dispositivo supraconductor cuántico, Faisabilité, Feasibility, Practicabilidad, Formation image, Imaging, Formación imagen, Imagerie RMN, Nuclear magnetic resonance imaging, Imaginería RMN, Mesure bruit, Noise measurement, Modèle mathématique, Mathematical model, Modelo matemático, Modélisation, Modeling, Modelización, Méthode directe, Direct method, Método directo, Résonance magnétique nucléaire, Nuclear magnetic resonance, Resonancia magnética nuclear, -Biomagnetism, SQUID, neural currents, ultra-low field NMR
Document Type:
Conference Conference Paper
File Description:
text
Language:
English
Author Affiliations:
Applied Modern Physics Group, Los Alamos National Laboratory, MS D454, Los Alamos, NM 87545, United States
ISSN:
1051-8223
Access URL:
http://pascal-francis.inist.fr/vibad/index.php?action=search&terms=19010330
Rights:
Copyright 2007 INIST-CNRS
CC BY 4.0
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Notes:
Electronics
Accession Number:
edscal.19010330
Database:
PASCAL Archive

Further Information

-Modern high field (HF) MRI uses magnetic fields greater than 1.5 T to yield exquisite anatomical features. We have also seen an explosion in functional MRI in the last decade that measures hemodynamic responses that are ultimately sluggish (∼one sec) and only indirectly related to electrophysiological processes. Magnetoencephalography (MEG) is a direct measure of the external fields generated by neuronal currents with exquisite temporal information (less than one msec). Spatial localization, however, is inferred from modeling priors, making MEG imaging only indirect at best. Ultra low field (ULF) MRI has recently been demonstrated with 2-3 mm resolution using fields in the microtesla regime. While the nuclear magnetic resonance (NMR) signal at ULF is dramatically weaker than at HF, we acquired high signal-to-noise measurements for a variety of samples at ULF using SQUID technology. Several researchers have proposed that electrophysiological activity may interact with the nuclear spins in a volume of interest, causing measurable variations in the NMR signal. We have developed a new approach to directly measuring neuronal activity with SQUID-based ULF-NMR techniques based on the hypothesis that interactions between the spin population and neural activity in cortex can be dominated by resonant mechanisms unique to ULF. We have experimentally demonstrated the feasibility of this approach via ULF-NMR using a single-channel SQUID system.