Result: Use of DNA nanodevices in modulating the mechanical properties of polyacrylamide gels

Title:
Use of DNA nanodevices in modulating the mechanical properties of polyacrylamide gels
Authors:
YURKE, Bernard, LIN, David C, LANGRANA, Noshir A
Source:
DNA computing (11th international workshop on DNA computing, DNA11, London, ON, Canada, June 6-9, 2005)0DNA 11. :417-426
Publisher Information:
Berlin; New York: Springer, 2006.
Publication Year:
2006
Physical Description:
print, 21 ref 1
Original Material:
INIST-CNRS
Subject Terms:
Computer science, Informatique, Sciences exactes et technologie, Exact sciences and technology, Sciences appliquees, Applied sciences, Informatique; automatique theorique; systemes, Computer science; control theory; systems, Informatique théorique, Theoretical computing, Algorithmique. Calculabilité. Arithmétique ordinateur, Algorithmics. Computability. Computer arithmetics, Calcul ADN, DNA computation, Càlculo ADN, Calcul moléculaire, Molecular computation, Càlculo molecular, DNA, Génie biomédical, Biomedical engineering, Ingeniería biomédica, Médicament, Drug, Medicamento, Propriété mécanique, Mechanical properties, Propiedad mecánica, Tissu, Tissue, Tejido
Document Type:
Conference Conference Paper
File Description:
text
Language:
English
Author Affiliations:
Bell Laboratories, 600 Mountain Ave, Murray Hill, NJ 07974, United States
Department of Mechanical and Aerospace Engineering, Rutgers University, Piscataway, NJ 08854, United States
ISSN:
0302-9743
Access URL:
http://pascal-francis.inist.fr/vibad/index.php?action=search&terms=19130922
Rights:
Copyright 2007 INIST-CNRS
CC BY 4.0
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Notes:
Computer science; theoretical automation; systems
Accession Number:
edscal.19130922
Database:
PASCAL Archive

Further Information

Here we show that bulk materials can be given new properties through the incorporation of DNA-based nanodevices. In particular, by employing simple nanodevices as crosslinks in polyacrylamide gels we have made the mechanical properties of these gels responsive to the presence of particular DNA strands. Two examples will be focused on here. One consists of a polymer system that can be switched between a sol and a gel state though the application of DNA strands that either form crosslinks or remove crosslinks. The other consists of a hydrogel whose crosslinks incorporate a motor domain. The stiffness of this hydrogel can be altered through the application of fuel strands, which stiffen and lengthen the crosslinks, or through the application of removal strands which remove the fuel strands form the motor domain. Such DNA-responsive gels may find applications in biomedical technology ranging from drug delivery to tissue engineering.