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Treffer: Miniaturization of Pressure Filtration Processes for Lean Development

Title:
Miniaturization of Pressure Filtration Processes for Lean Development
Authors:
JERMANN, Simon, SCHREINER, Andreas, SCHNEEBERGER, Ricardo
Source:
Particle TechnologyChemical engineering & technology. 32(7):1088-1094
Publisher Information:
Weinheim: Wiley-VCH, 2009.
Publication Year:
2009
Physical Description:
print, 10 ref
Original Material:
INIST-CNRS
Subject Terms:
Chemical engineering, Génie chimique, Sciences exactes et technologie, Exact sciences and technology, Sciences appliquees, Applied sciences, Genie chimique, Chemical engineering, Séparations mécaniques liquide-liquide et fluide-solide, Liquid-liquid and fluid-solid mechanical separations, Filtration, Aire superficielle, Surface area, Area superficial, Effet échelle, Scale effect, Efecto escala, Extrapolation, Extrapolación, Facteur correction, Correction factor, Factor corrección, Filtration, Filtración, Génie des procédés, Process engineering, Ingeniería procesos, Miniaturisation, Miniaturization, Miniaturización, Perméabilité, Permeability, Permeabilidad
Document Type:
Fachzeitschrift Article
File Description:
text
Language:
English
Author Affiliations:
Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland
Pharmaceutical and Analytical Development, Novartis Pharma AG, Basel, Switzerland
ISSN:
0930-7516
Access URL:
http://pascal-francis.inist.fr/vibad/index.php?action=search&terms=21826102
Rights:
Copyright 2009 INIST-CNRS
CC BY 4.0
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Notes:
Chemical engineering
Accession Number:
edscal.21826102
Database:
PASCAL Archive

Weitere Informationen

As a basic operation of mechanical process engineering, pressure filtration and its scale-up has been described in detail in the literature. But, the pharmaceutical development of active substances, in particular, calls for a scale-up of relatively small quantities to execute downstream processes in a lean and reliable manner. Therefore, development depends on conclusions from smaller filter equipment. In this study, results from laboratory nutsche filters with filter surface areas of 1.4 cm2 and 9.6 cm2 were compared with results from a 20 cm2 nutsche. It has been shown that no reproducible and reliable data could be generated using the 1.4-cm2 nutsche. While this was possible using the 9.6 cm2 nutsche, the permeability was greater than with the recommended 20 cm2 nutsche so that a correction factor has to be introduced.