Result: Modeling and identification of a nonlinear hybrid dynamical system in batch fermentation of glycerol
School of Energy and Engineering, Dalian University of Technology, Dalian, Liaoning 116024, China
School of Environmental and Biological Science and Technology, Dalian University of Technofogy, Dalian, Liaoning 116012, China
CC BY 4.0
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Further Information
A nonlinear hybrid dynamical system is established to describe the batch culture of glycerol to 1,3-propanediol (1,3-PD) by Klebsiella pneumoniae (K. pneumoniae), in which glycerol is assumed to pass the cell membrane by passive diffusion coupled with facilitated transport and transport mechanism of 1,3-PD is assumed to be uncertain. The existence, uniqueness and continuity of solutions are also discussed. To infer the most reasonable transport mechanism of 1,3-PD, a system identification model consisting of both discrete and continuous variables is proposed. Additionally, we construct a two-phase optimization algorithm on the basis of modified complex method together with very fast simulated annealing technology. Numerical results show that it is most reasonable for 1,3-PD to pass the cell membrane by passive diffusion coupled with facilitated transport and that the optimization algorithm is valid.