Treffer: MATHEMATICAL AND NUMERICAL ANALYSIS OF A MODEL FOR ANTI-ANGIOGENIC THERAPY IN METASTATIC CANCERS

Title:
MATHEMATICAL AND NUMERICAL ANALYSIS OF A MODEL FOR ANTI-ANGIOGENIC THERAPY IN METASTATIC CANCERS
Source:
Modélisation mathématique et analyse numérique (Imprimé). 46(2):207-237
Publisher Information:
Les Ulis: EDP Sciences, 2012.
Publication Year:
2012
Physical Description:
print, 27 ref
Original Material:
INIST-CNRS
Document Type:
Fachzeitschrift Article
File Description:
text
Language:
English
Author Affiliations:
LATP, UMR 6632. Université de Provence, Technopole Château-Gombert, 39 rue F. Joliot Curie, 13453 Marseille, France
Laboratoire de Toxicocinétique et Pharmacocinétique UMR-MD3, 27 boulevard Jean Moulin, 13005 Marseille, France
ISSN:
0764-583X
Rights:
Copyright 2015 INIST-CNRS
CC BY 4.0
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Notes:
Mathematics
Accession Number:
edscal.25563556
Database:
PASCAL Archive

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We introduce a phenomenological model for anti-angiogenic therapy in the treatment of metastatic cancers. It is a structured transport equation with a nonlocal boundary condition describing the evolution of the density of metastases that we analyze first at the continuous level. We present the numerical analysis of a lagrangian scheme based on the characteristics whose convergence establishes existence of solutions. Then we prove an error estimate and use the model to perform interesting simulations in view of clinical applications.