Treffer: Messungen der retinalen Nervenfaserschichtdicke mittels Laserpolarimetrie bei Patienten mit AIDS in Vergleich zu Gesunden unter Berücksichtigung computerperimetrischer Befunde : eine Pilotsudie unter Einsatz des Nerve-Fiber Analyzer® / Measurements of nerve-fiber-layer thickness in AIDS patients compared to healthy probationers considering findings in computerized perimetry.A pilot study using the Nerve-Fiber-AnalyzerTM
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Background Several authors postulated a retinal nerve-fiber loss in HIV-infection because of functional alterations (reduced colour sensitivity, alterations in perimetry). This hypothesis has been reevaluated for the first time by means of direct in-vivo measurement of the retinal nervefiber-layer thickness by laser polarimetry using the Nerve-Fiber-Analyzer. Patients and methods Retinal nerve-fiber-layer thickness in 14 eyes of 7 patients has been compared to equally-sided eyes of equally-aged healthy controls. Visual fields showed a bilateral diffuse sensitivity reduction in 5 patients. Visual fields of 2 patients and all healthy controls were normal. Results A significant difference in measurement values of nerve-fiber-layer thickness did not show between AIDS-patients and healthy controls. There was no correlation between visual field alterations and measurement values of nerve-fiber-layer thickness. Conclusion In AIDS patients, a retinal nerve-fiber loss corresponding to their visual-field alterations has not been found. However, these visual-field alterations may also be explained by central-nervous disorders, lens opacifications or neuro-retinal disfunctions without nerve-fiber loss.