Treffer: Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate
Title:
Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate
Authors:
Source:
Veterinary Research. 56(1):73-73
Publisher Information:
CCSD; BioMed Central, 2025.
Publication Year:
2025
Collection:
collection:ARINRAE-VR
collection:ARINRAE
collection:ARINRAE
Subject Terms:
Original Identifier:
HAL: hal-05019844
Document Type:
Zeitschrift
article<br />Journal articles
Language:
English
ISSN:
0928-4249
1297-9716
1297-9716
Relation:
info:eu-repo/semantics/altIdentifier/doi/10.1186/s13567-025-01507-x
DOI:
10.1186/s13567-025-01507-x
Access URL:
Rights:
info:eu-repo/semantics/OpenAccess
Accession Number:
edshal.hal.05019844v1
Database:
HAL
Weitere Informationen
Type II reference isolates of Toxoplasma gondii are widely used in animal toxoplasmosis models, but studies with Type III isolates remain scarce. In addition, these methods often rely on laboratory-adapted parasite stages that may not reflect natural infection. This study presents a new murine model based on an oral infection with oocysts from a recently obtained Type III isolate, TgShSp24, which exhibited remarkable morbidity and a distinct tissue distribution during chronic infection, differing from the recently obtained Type II isolate TgShSp1. This novel model aims to better mimic natural infection and provides a valuable tool for testing drugs and vaccines.