Treffer: Reconstruction of switching thresholds in piecewise-affine models of genetic regulatory networks
Title:
Reconstruction of switching thresholds in piecewise-affine models of genetic regulatory networks
Contributors:
Computer science and genomics (HELIX), Centre Inria de l'Université Grenoble Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF), Applications and Tools of Automatic Control (SOSSO2), Inria Paris-Rocquencourt, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), João Hespanha, Ashish Tiwari
Source:
Hybrid Systems: Computation and Control. :184-199
Publisher Information:
CCSD; Springer Berlin / Heidelberg, 2006.
Publication Year:
2006
Collection:
collection:UGA
collection:CNRS
collection:INRIA
collection:UNIV-GRENOBLE1
collection:UNIV-LYON1
collection:INRIA-RHA
collection:INRIA-ROCQ
collection:INRIA_TEST
collection:GIP-BE
collection:TESTALAIN1
collection:BIOENVIS
collection:INRIA2
collection:INRIA-RENGRE
collection:LBBE
collection:UDL
collection:UNIV-LYON
collection:TEST-UGA
collection:CNRS
collection:INRIA
collection:UNIV-GRENOBLE1
collection:UNIV-LYON1
collection:INRIA-RHA
collection:INRIA-ROCQ
collection:INRIA_TEST
collection:GIP-BE
collection:TESTALAIN1
collection:BIOENVIS
collection:INRIA2
collection:INRIA-RENGRE
collection:LBBE
collection:UDL
collection:UNIV-LYON
collection:TEST-UGA
Subject Terms:
Hybrid system, Genetic regulatory network, system identification, switching thresholds reconstruction, ACM: C.: Computer Systems Organization, C.1: PROCESSOR ARCHITECTURES, C.1.3: Other Architecture Styles, C.1.3.5: Heterogeneous (hybrid) systems, ACM: I.: Computing Methodologies, I.6: SIMULATION AND MODELING, I.6.1: Simulation Theory, I.6.1.1: Systems theory, [SDV.OT]Life Sciences [q-bio], Other [q-bio.OT]
Original Identifier:
HAL:
Document Type:
Konferenz
conferenceObject<br />Conference papers
Language:
English
Relation:
info:eu-repo/semantics/altIdentifier/doi/10.1007/11730637
DOI:
10.1007/11730637
Access URL:
Rights:
info:eu-repo/semantics/OpenAccess
Accession Number:
edshal.inria.00001225v1
Database:
HAL
Weitere Informationen
Recent advances of experimental techniques in biology have led to the production of enormous amounts of data on the dynamics of genetic regulatory networks. In this paper, we present an approach for the identification of PieceWise-Affine (PWA) models of genetic regulatory networks from experimental data, focusing on the reconstruction of switching thresholds associated with regulatory interactions. In particular, our method takes into account geometric constraints specific to models of genetic regulatory networks. We show the feasibility of our approach by the reconstruction of switching thresholds in a PWA model of the carbon starvation response in the bacterium Escherichia coli.