Result: Suspicion and referral of patients with transthyretin amyloid cardiomyopathy: Recommendations by a Portuguese multidisciplinary expert panel

Title:
Suspicion and referral of patients with transthyretin amyloid cardiomyopathy: Recommendations by a Portuguese multidisciplinary expert panel
Authors:
Dulce Brito, João Agostinho, Carlos Aguiar, Sílvia Aguiar Rosa, Nuno Cardim, Cândida Fonseca, Nuno Marques, Pedro Moraes Sarmento, Patrícia Rodrigues, Jonathan Santos, Maria João Vidigal Ferreira, Olga Azevedo
Source:
Revista Portuguesa de Cardiologia, Vol 44, Iss, Pp 59-68 (2025)
Publisher Information:
Elsevier BV, 2025.
Publication Year:
2025
Subject Terms:
Amyloid Neuropathies, Familial, Amiloidose cardíaca, Portugal, Diagnóstico, Referenciação, Miocardiopatia por amiloidose de transtirretina, Consenso, Algoritmo, RC666-701, Diseases of the circulatory (Cardiovascular) system, Humans, Cardiomyopathies, Referral and Consultation, Algorithms
Document Type:
Academic journal Article
Language:
English
ISSN:
0870-2551
DOI:
10.1016/j.repc.2024.12.002
Access URL:
https://pubmed.ncbi.nlm.nih.gov/39956764
https://doaj.org/article/7f9e060d1d7148a381d042103468a398
Rights:
CC BY NC ND
Accession Number:
edsair.doi.dedup.....3f15ba94279bbc4c1f8df40a4388938b
Database:
OpenAIRE

Further Information

Early diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) is crucial for better disease management and outcome. To ensure timely diagnosis, a multidisciplinary panel of Portuguese experts, including cardiologists, internal medicine specialists, and general practitioners, have developed a national consensus to aid physicians in enhancing the referral of patients with suspicion of ATTR-CM in Portugal. A structured approach was used to develop the consensus: (1) an online survey aimed at identifying clinical red flags, patient journeys, and diagnostic tools related to ATTR-CM; (2) a face-to-face roundtable meeting where the survey findings were discussed and a consensus was reached on referral and diagnostic algorithms for ATTR-CM in Portugal; and (3) critical review of the proposed algorithms. The referral and diagnostic algorithms for ATTR-CM in Portugal were developed considering current recommendations, but also the existence of a nationwide network of specialized cardiomyopathy clinics and national reference centers for familial amyloid polyneuropathy due to the endemic p.V50M variant. This collaborative effort aims to enhance awareness, facilitate timely referrals and improve early diagnosis, ultimately ensuring better management of ATTR-CM patients in Portugal.